We report a case of fulminant hepatitis in a hepatitis B surface antigen (HBsAg)-positive patient with aggressive adult T-cell leukemia-lymphoma who received monotherapy with an anti-CCR4 monoclonal antibody, mogamulizumab, with decreased hepatitis B virus (HBV)- DNA levels by entecavir prophylaxis. Although HBV reactivation-related hepatitis was considered in the differential diagnosis, the patient did not meet the conventional criteria for HBV reactivation and was finally diagnosed with drug-induced hepatitis. Considering that the immunoenhancing effects of mogamulizumab can lead to HBV reactivation-related hepatitis in HBsAg-positive patients, we should differentiate drug-induced hepatitis from HBV reactivation, especially in patients receiving immunomodulatory drugs, if HBV-DNA levels are reduced by antiviral prophylaxis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/hepr.14057 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Fatal hepatitis after pembrolizumab in combination therapy with carboplatin and pemetrexed].
Ugeskr Laeger
December 2024
Lever-, Mave- og Tarmsygdomme, Aarhus Universitetshospital.
Immunotherapy-induced hepatitis is a well-known and relatively common side effect of immune checkpoint inhibitors. It is usually mild to moderate and responds well to corticosteroids with a full recovery. However, in rare cases, severe liver injury may develop, leading to fulminant liver failure.
View Article and Find Full Text PDFTaraxasterol extracted from Ixeridium gramineum (Fisch.) Tzvel. Attenuated D-GalN/LPS-induced fulminant hepatitis by modulating the JAK/STAT and TNF signalling pathways.
J Ethnopharmacol
December 2024
Department of Anesthesiology, Affiliated hospital of Guilin Medical University, China. Electronic address:
Ethnopharmacological Relevance: Taraxasterol (TAR), a compound highly abundant and easily obtainable from Tibetan medicine Ixeridium gramineum (Fisch.) Tzvel., exhibits a variety of biological effects, including hepatoprotective, anti-inflammatory, and antioxidant activities.
View Article and Find Full Text PDFA Rare Case of Weil's Disease Presenting With Severe Hyperbilirubinemia and Acute Kidney Injury: A Diagnostic Challenge in Urban England.
Cureus
November 2024
Internal Medicine, Northumbria Healthcare NHS Trust, Newcastle-Upon-Tyne, GBR.
We present a rare and challenging case of Weil's disease in a patient who was admitted to the Critical Care Unit with a clinical suspicion of the condition. The patient showed a prompt response to treatment before laboratory confirmation was obtained. Leptospirosis, a zoonotic disease, is most commonly found in tropical and temperate regions.
View Article and Find Full Text PDFAcute Viral Hepatitis E Presenting With Bell's Palsy and Acute Pancreatitis: A Case Report.
Cureus
November 2024
Gastroenterology, King George's Medical University, Lucknow, IND.
Hepatitis E is a hepatotropic virus and the most common cause of acute viral hepatitis among adults in India. It has four genotypes, and genotype 1 is mostly associated with sporadic cases. It typically causes self-limiting acute hepatitis following a prodromal course.
View Article and Find Full Text PDFValidation of prognostic scores for predicting acute liver failure and in-hospital death in patients with dengue-induced severe hepatitis.
World J Gastroenterol
December 2024
Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Article Synopsis
- Acute liver failure (ALF) in dengue patients is uncommon but highly fatal; identifying those at risk is crucial for improving survival rates.
- A study involving 2532 dengue patients revealed that factors like international normalized ratio, bilirubin, albumin, and creatinine can predict the likelihood of ALF and in-hospital mortality in patients with dengue-induced severe hepatitis (DISH).
- Several prognostic scores, including the MELD score and ALBI score, effectively predicted ALF and mortality, demonstrating high sensitivity and specificity in clinical assessments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!