Introduction: Cancer is one of the most significant health challenges demanding the expansion of effectual therapeutic methods. Triple-negative breast cancer (TNBC) is a form of aggressive cancer with inadequate therapeutic options which lacks the expression of certain hormones.
Materials And Methods: The present study investigates the potential of naringenin-7-O-glucoside, a flavanone glycoside extracted from as an anticancer agent against TNBC cell lines. In-vitro analysis to evaluate cytotoxicity, apoptotic-inducing properties and effect on gene expression was conducted.
Results: MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay studied the IC-50 of naringenin-7-O-glucoside to be 233.56 µg/µL, revealing the dose-dependent cytotoxicity with minimal effect on Vero cells. Extensive DNA fragmentation confirmed the apoptotic property. Furthermore, a significant downregulation of the epidermal growth factor receptor (EGFR) was noted in treated cells when equated to the control specimen of the sample.
Conclusion: Therefore, naringenin-7-O-glucoside can be a potential targeted therapeutic agent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104259 | PMC |
| http://dx.doi.org/10.7759/cureus.58634 | DOI Listing |
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