AI Article Synopsis
- Recent advancements in Alzheimer's disease (AD) diagnostics and treatments show promise, but there's still a significant need for effective therapies, indicating that more research is essential.
- Evidence suggests that microbial infections could play a role in AD, with specific bacteria like Chlamydia pneumoniae (Cp) being frequently found in the brains of AD patients.
- Despite its presence in AD brains, there is currently no conclusive research proving whether Cp directly causes or contributes to AD progression, prompting a discussion of potential mechanisms connecting Cp to AD pathology.
Article Abstract
While recent advances in diagnostics and therapeutics offer promising new approaches for Alzheimer's disease (AD) diagnosis and treatment, there is still an unmet need for an effective remedy, suggesting new avenues of research are required. Besides many plausible etiologies for AD pathogenesis, mounting evidence supports a possible role for microbial infections. Various microbes have been identified in the postmortem brain tissues of human AD patients. Among bacterial pathogens in AD, (Cp) has been well characterized in human AD brains and is a leading candidate for an infectious involvement. However, no definitive studies have been performed proving or disproving Cp's role as a causative or accelerating agent in AD pathology and cognitive decline. In this review, we discuss recent updates for the role of Cp in human AD brains as well as experimental models of AD. Furthermore, based on the current literature, we have compiled a list of potential mechanistic pathways which may connect Cp with AD pathology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102982 | PMC |
| http://dx.doi.org/10.3389/fnins.2024.1393293 | DOI Listing |
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