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Photosensitizer spatial heterogeneity and its impact on personalized interstitial photodynamic therapy treatment planning.
J Biomed Opt
January 2025
University of Toronto, University Health Network, Princess Margaret Cancer Centre, Department of Medical Biophysics, Toronto, Ontario, Canada.
Significance: Personalized photodynamic therapy (PDT) treatment planning requires knowledge of the spatial and temporal co-localization of photons, photosensitizers (PSs), and oxygen. The inter- and intra-subject variability in the photosensitizer concentration can lead to suboptimal outcomes using standard treatment plans.
Aim: We aim to quantify the PS spatial variation in tumors and its effect on PDT treatment planning solutions.
Fluorescence tunable carbon dots for nuclear dynamics and gastrointestinal imaging in live zebrafish and their toxicity evaluation by cardio-craniofacial disfunction assessment.
Nanoscale
January 2025
Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085, India.
Sub-cellular organelle anomalies are frequently observed in diseases such as cancer. Early and precise diagnosis of these alterations can be crucial for patient outcomes. However, current diagnostic tools using conventional organic dyes or metal quantum dots face limitations, including poor biocompatibility, stringent storage conditions, limited solubility in aqueous media, and slow staining speeds.
View Article and Find Full Text PDFEvaluating the efficacy of cavity disinfection using methylene blue dye with 660-nm diode laser on primary molars: An in vivo study.
J Indian Soc Pedod Prev Dent
October 2024
Department of Pediatric and Preventive Dentistry, Maratha Mandal's Nathajirao G. Halgekar Institute of Dental Sciences and Research Centre, Belagavi, Karnataka, India.
Background And Objectives: The purpose of this study was to evaluate the antimicrobial activity of methylene blue dye with 660-nm diode laser in cavity disinfection and to compare the total bacterial count in dentinal samples preexcavation, postexcavation, and postdisinfection. The study design was experimental in vivo.
Materials And Methods: Fifteen children aged 5-12 years with 15 primary molars requiring atraumatic restorative treatment (ART) were selected.
Can α-Mangostin and Photodynamic Therapy Support Ciprofloxacin in the Inactivation of Uropathogenic and Strains?
Int J Mol Sci
December 2024
Department of Biology and Medical Parasitology, Faculty of Medicine, Wrocław Medical University, Mikulicza-Radeckiego 9, 50-345 Wroclaw, Poland.
Multidrug-resistant bacteria represent a significant challenge in the treatment of bacterial infections, often leading to therapeutic failures. This issue underlines the need to develop strategies that improve the efficacy of conventional antibiotic therapies. In this study, we aimed to assess whether a plant-derived compound, α-mangostin, and photodynamic therapy (PDT) could enhance the antibacterial activity of ciprofloxacin against uropathogenic strains of and .
View Article and Find Full Text PDFDiscovering Cell-Targeting Ligands and Cell-Surface Receptors by Selection of DNA-Encoded Chemical Libraries against Cancer Cells without Predefined Targets.
Angew Chem Int Ed Engl
January 2025
University of Hong Kong, Chemistry, Department of Chemistry, Pokfulam Road, N.A., Hong Kong, HONG KONG.
Small molecules that can bind to specific cells have broad applications in cancer diagnosis and treatment. Screening large chemical libraries against live cells is an effective strategy for discovering cell-targeting ligands. The DNA-encoded chemical library (DEL or DECL) technology has emerged as a robust tool in drug discovery and has been successfully utilized in identifying ligands for biological targets.
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