Presented paper deals with a novel application of the (nonlinear) logistic equation to model an elimination of microscopic filaments types of fungi-molds from affected materials via different external inactivation techniques. It is shown that if the inactivation rate of the external source is greater than the maximum natural growth rate of mycelium, the mold colony becomes destroyed after a finite time. Otherwise, the mycelium may survive the external attack only at a sufficiently large initial concentration of the inoculum. Theoretically determined growth curves are compared with the experimental data for Aspergillus brasiliensis mold inactivated by using both cold atmospheric plasma (CAP) and UV-germicidal lamp. Model presented in the article may be applied also to other classes of microorganisms (e.g. bacteria).
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http://dx.doi.org/10.1038/s41598-024-60812-1 | DOI Listing |
BMC Microbiol
March 2025
Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
Background: Outer membrane protein OmpA is composed of two domains, an N-terminal β-barrel structure embedded in the outer membrane and a C-terminal globular domain noncovalently associated with the peptidoglycan layer in periplasm. Stenotrophomonas maltophilia KJ is a clinical isolate. In our recent study, we disclosed that KJ∆OmpA an OmpA C-terminal deletion mutant, compromised menadione tolerance.
View Article and Find Full Text PDFNat Commun
March 2025
Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC, USA.
The microenvironment is a rich source of new cancer targets. We thus used a targeted single-guide RNA library to screen a panel of human pancreatic cancer lines for genes uniquely affecting tumorigenesis. Here we show inactivation of the Adapter Protein complex-2 of clathrin-mediated endocytosis reduces cell growth in vitro, but completely oppositely, promotes tumor growth in vivo.
View Article and Find Full Text PDFIntroduction: Group B Streptococcus (GBS) colonization lead to placental infection and inflammation, known as chorioamnionitis (CA). Fetal exposure to CA is linked to elevated risks of neurobehavioral impairments in offspring, including autism spectrum disorder, which is more prominent in males than females. In our preclinical model of GBS-induced CA, males exhibited heightened placental inflammation compared to females, correlating with more severe subsequent neurobehavioral impairments.
View Article and Find Full Text PDFFood Res Int
March 2025
College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, China. Electronic address:
This research endeavor delved into the bactericidal mechanisms of CAP against Pseudomonas aeruginosa (P. aeruginosa), employing both protein oxidation and transcriptome analysis for a comprehensive understanding. The findings unveiled that CAP treatment, through the generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), induced direct cell membrane disruption and intracellular protein oxidation.
View Article and Find Full Text PDFLife (Basel)
February 2025
Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Vitamin C is an organic compound biosynthesized in plants and most vertebrates. Since its discovery, the benefits of vitamin C use in the cure and prevention of various pathologies have been frequently reported, including its anti-oxidant, anti-inflammatory, anticoagulant, and immune modulatory properties. Vitamin C plays an important role in collagen synthesis and subsequent scurvy prevention.
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