AI Article Synopsis
- * Recent research has advanced the understanding of how astrocyte Ca signaling operates, including techniques for imaging and manipulating these signals to study their effects on neural activity and behavior.
- * The review identifies relationships between astrocyte Ca signals and neural circuit functioning, suggesting a framework for interpreting behavioral studies, while also highlighting new research opportunities in the field.
Article Abstract
Astrocytes are predominant glial cells that tile the central nervous system and participate in well-established functional and morphological interactions with neurons, blood vessels, and other glia. These ubiquitous cells display rich intracellular Ca signaling, which has now been studied for over 30 years. In this review, we provide a summary and perspective of recent progress concerning the study of astrocyte intracellular Ca signaling as well as discussion of its potential functions. Progress has occurred in the areas of imaging, silencing, activating, and analyzing astrocyte Ca signals. These insights have collectively permitted exploration of the relationships of astrocyte Ca signals to neural circuit function and behavior in a variety of species. We summarize these aspects along with a framework for mechanistically interpreting behavioral studies to identify directly causal effects. We finish by providing a perspective on new avenues of research concerning astrocyte Ca signaling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444304 | PMC |
| http://dx.doi.org/10.1101/cshperspect.a041353 | DOI Listing |
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