AI Article Synopsis
- Even though there have been improvements in cancer treatment, pancreatic cancer is still hard to treat with targeted therapies, so doctors mostly use combinations of chemotherapy.
- This review looks at different treatments being tested for pancreatic ductal adenocarcinoma (PDAC), focusing on well-known targets like KRAS and new ones like P53.
- Experts believe it's going to take time to find better targeted treatments for PDAC, and they suggest using combinations of drugs instead of just one.
Article Abstract
Introduction: Despite the considerable progress made in cancer treatment through the development of target therapies, pancreatic ductal adenocarcinoma (PDAC) continues to exhibit resistance to this category of drugs. As a result, chemotherapy combination regimens remain the primary treatment approach for this aggressive cancer.
Areas Covered: In this review, we provide an in-depth analysis of past and ongoing trials on both well-known and novel targets that are being explored in PDAC, including PARP, EGFR, HER2, KRAS, and its downstream and upstream pathways (such as RAF/MEK/ERK and PI3K/AKT/mTOR), JAK/STAT pathway, angiogenesis, metabolisms, epigenetic targets, claudin, and novel targets (such as P53 and plectin). We also provide a comprehensive overview of the significant trials for each target, allowing a thorough glimpse into the past and future of target therapy.
Expert Opinion: The path toward implementing a target therapy capable of improving the overall survival of PDAC is still long, and it is unlikely that a monotherapy target drug will fulfill a meaningful role in addressing the complexity of this cancer. Thus, we discuss the future direction of target therapies in PDAC, trying to identify the more promising target and combination treatments, with a special focus on the more eagerly awaited ongoing trials.
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| http://dx.doi.org/10.1080/14737140.2024.2357802 | DOI Listing |
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