AI Article Synopsis
- The study investigated the long-term effects of combining topography-guided photorefractive keratectomy (PRK) and accelerated corneal collagen cross-linking (CXL) for treating mild-to-moderate keratoconus using a specific refractive system.
- Conducted at a tertiary eye care hospital in South India, the study involved 30 patients whose visual acuity and keratometry measurements were evaluated at multiple time points post-surgery.
- Results showed significant improvements in uncorrected and corrected distance visual acuity, as well as decreased keratometry values over 24 months, suggesting this combined procedure could be an effective treatment for early keratoconus, though further research is needed to solidify these
Article Abstract
Purpose: This study aimed to report the long-term results of combined topography-guided photorefractive keratectomy (PRK) and accelerated corneal collagen cross-linking (CXL) for keratoconus using the Zeiss refractive coordinated system.
Methods: A prospective interventional study was conducted in a tertiary eye care hospital in South India. Patients with mild-to-moderate progressive keratoconus and corneal pachymetry greater than 450 µm were included. They underwent customized topography-guided PRK followed by CXL. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and keratometry readings and complications were evaluated at 1, 3, 6, 12, and 24 months postoperatively.
Results: Thirty patients (30 eyes) were included in the study. All study parameters showed a statistically significant improvement postoperatively over baseline values. At 24 months, the mean UDVA improved from 0.8 ± 0.180 logarithm of the minimum angle of resolution (logMAR) to 0.38 ± 0.118 logMAR ( P -value <0.001) and CDVA improved from 0.467 ± 0.142 logMAR to 0.227 ± 0.078 logMAR ( P -value <0.001). The mean flat, steep, and maximum keratometry values were significantly reduced by 2.133, 3, and 4.54 diopters, respectively, at the last follow-up examination ( P -value <0.001).
Conclusion: The combined topography-guided PRK and accelerated CXL procedure seem to be a promising treatment alternative for early keratoconus. This is the first such study on the Zeiss refractive coordinated system. However, further studies with a larger study population and longer follow-up periods are required to draw final conclusions about the benefits of this procedure in keratoconus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11338431 | PMC |
| http://dx.doi.org/10.4103/IJO.IJO_791_23 | DOI Listing |
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Article Synopsis
- The study investigated the long-term effects of combining topography-guided photorefractive keratectomy (PRK) and accelerated corneal collagen cross-linking (CXL) for treating mild-to-moderate keratoconus using a specific refractive system.
- Conducted at a tertiary eye care hospital in South India, the study involved 30 patients whose visual acuity and keratometry measurements were evaluated at multiple time points post-surgery.
- Results showed significant improvements in uncorrected and corrected distance visual acuity, as well as decreased keratometry values over 24 months, suggesting this combined procedure could be an effective treatment for early keratoconus, though further research is needed to solidify these
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