New lignans from .

Nat Prod Res

Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China.

Published: May 2024

A new lignan phyllanins A () and a lignan phyllanins B () for which the absolute configuration was determined for the first time, along with four known lignans (-) were isolated from the branch and leaf extracts of . Their planar structures were mainly determined by a combination of 1D and 2D NMR, HRESIMS spectral analyses, and the absolute configurations of the compounds and were established by DFT GIAO C NMR and electronic circular dichroism (ECD) calculations. In addition, all these six lignans were firstly tested for the antibacterial activities against MRSA, , , and . Among these compounds, and showed potential antibacterial activities against MRSA and with MIC values of 4 and 8 µg/mL, respectively.

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Source
http://dx.doi.org/10.1080/14786419.2024.2356661DOI Listing

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