Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant .

Chem Commun (Camb)

School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHKSZ), Shenzhen, Guangdong 518172, China.

Published: June 2024

A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d4cc01022aDOI Listing

Publication Analysis

Top Keywords

aggregation-induced emission
8
emission photosensitizer
8
photosensitizer antibacterial
4
antibacterial therapy
4
therapy methicillin-resistant
4
methicillin-resistant cationic
4
cationic aggregation-induced
4
photosensitizer aie-ps
4
aie-ps mnnpybb
4
mnnpybb reported
4

Similar Publications

A novel aggregation-induced emission (AIE)-based artificial light-harvesting system (LHS) is successfully assembled via the host-guest interaction of bis-naphthylacrylonitrile derivative (BND), water-soluble pillar[5]arene (WP5), and sulforhodamine 101 (SR101). After host-guest assembly, the formed WP5⊃BND complexes spontaneously self-aggregated into WP5⊃BND nanoparticles (donors) and SR101 (acceptors) is introduced into WP5⊃BND to fabricate WP5⊃BND-SR101 LHS. Through the investigation of energy transfer between donors and acceptors, the artificial light-harvesting processes are certified in WP5⊃BND-SR101 LHS and the absolute fluorescence quantum yields (Φ) are significantly improved from 8.

View Article and Find Full Text PDF

The Midas Touch by Iridium: A Second Near-Infrared Aggregation-Induced Emission-Active Metallo-Agent for Exceptional Phototheranostics of Breast Cancer.

J Am Chem Soc

January 2025

Center for AIE Research, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, P. R. China.

Developing small organic molecular phototheranostic agents with second near-infrared (NIR-II) aggregation-induced emission (AIE) is paramount for the phototriggered diagnostic imaging and synchronous in situ therapy of cancer via an excellent balance of the excited states energy dissipations. In this study, a multifunctional iridium(III) complex is exploited by the coordination of an AIE-active N^N ancillary ligand with a trivalent iridium ion. The resultant complex DPTPzIr significantly outperforms its parent ligand in terms of absorption/emission wavelengths, reactive oxygen species (ROS) production, and photothermal conversion, which simultaneously endow DPTPzIr nanoparticles with matched absorption peak to commercial 808 nm laser, the longest NIR-II emission peak (above 1100 nm) among those previously reported AIE iridium(III) complexes, potentiated type-I ROS generation, and as high as 60.

View Article and Find Full Text PDF

Wet Photolithography From Hydrogen Abstraction of a Quasi-Orthogonal Aggregation-Induced Emitter.

Adv Sci (Weinh)

January 2025

Center of Super-Diamond and Advanced Films (COSDAF) and Department of Chemistry, City University of Hong Kong, Hong Kong SAR, 999077, P. R. China.

A new aggregation-induced emission (AIE) luminogen is obtained by dimerizing acridin-9(10H)-one (Ac), an aggregation-caused quenching (ACQ) effect monomer via an N─N bond and forming 9H,9'H-[10,10'-biacridine]-9,9'-dione (DiAc) with D symmetry. The quenching of DiAc in solution is ascribed to the enhanced basicity promoting hydrogen bonding and then a hydrogen abstraction (HA) reaction and/or an unallowed transition in frontier orbitals with the same symmetry facilitating intersystem crossing. It is found that emissive Ac is one product of the non-emissive DiAc solution in the HA reaction activated by UV irradiation.

View Article and Find Full Text PDF

Visualizing Endoplasmic Reticulum Stress and Autophagy in Alzheimer's Model Cells by a Peroxynitrite-Responsive AIEgen Fluorescent Probe.

ACS Chem Neurosci

January 2025

Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Endoplasmic reticulum (ER) stress and autophagy (ER-phagy) occurring in nerve cells are crucial physiological processes closely associated with Alzheimer's disease (AD). Visualizing the two processes is paramount to advance our understanding of AD pathologies. Among the biomarkers identified, peroxynitrite (ONOO) emerges as a key molecule in the initiation and aggravation of ER stress and ER-phagy, highlighting its significance in the underlying mechanisms of the two processes.

View Article and Find Full Text PDF

Flower-like tailored carbon nitride oligomer as an excellent aggregation-induced electrochemiluminescence emitter for sensitive immunoassay of neuron-specific enolase via dual quenching by bimetallic phenolic networks.

J Colloid Interface Sci

January 2025

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, PR China. Electronic address:

The adjustment of the electrochemiluminescence (ECL) of polymeric carbon nitride (CN) is essential for its application in sensitive immunoassays. However, such modification through aggregation-induced emission (AIE) has not yet been reported. Herein, aggregation-induced ECL in CN oligomer (CNO) was induced through the introduction of a rotatable imine moiety, with the resulting material exhibiting excellent performance in the targeted immunodetection of neuron-specific enolase.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!