Bioactive arabinogalactan from roots: characterization of gastroprotective and antioxidant potentials against drug-induced gastropathy.

Bristled ferula ( (Bunge) Pimenov) is a perennial plant belonging to the Apiaceae family, and its aqueous extract is utilised in Eastern medicine to treat digestive system diseases. In this study, water-soluble polysaccharides from were isolated for the first time, and the basic polymer FH-3 was separated and characterised. FH-3 was found to contain arabinose and galactose in a 1:5 ratio, with a molecular weight of 52.3 kDa. Methylation analysis confirmed the structure of FH-3 to be arabino-3,6-galactan. Administration of FH-3 at 10 and 30 mg/kg doses in rats with drug-induced gastropathy effectively limited the development of large and strip-like erosions in the gastric mucosa. FH-3 prevented the development of oxidative stress, normalising malondialdehyde (MDA) and catalase (CAT) and reducing glutathione (GSH) serum levels. Arabinogalactan FH-3 is a new gastroprotective and antioxidant plant component in roots, offering promising prospects for treating stomach diseases.