AI Article Synopsis
- Angiomotin (Amot) family members, including Amot, Amotl1, and Amotl2, interact with angiostatins and play significant roles in processes like embryonic development, angiogenesis, and tumorigenesis.
- They are involved in regulating important signaling pathways such as Hippo, AMPK, and mTOR, impacting neural stem cell differentiation and synaptic functions.
- The review consolidates studies on Amot family regulation and their physiological/pathological roles, aiming to provide insights for future cancer research and potential clinical applications.
Article Abstract
Angiomotin (Amot) family members, including Amot, Amot-like protein 1 (Amotl1) and Amot-like protein 2 (Amotl2), have been found to interact with angiostatins. In addition, Amot family members are involved in various physiological and pathological functions such as embryonic development, angiogenesis and tumorigenesis. Some studies have also demonstrated its regulation in signaling pathways such as the Hippo signaling pathway, AMPK signaling pathway and mTOR signaling pathways. Amot family members play an important role in neural stem cell differentiation, dendritic formation and synaptic maturation. In addition, an increasing number of studies have focused on their function in promoting and/or suppressing cancer, but the underlying mechanisms remain to be elucidated. The present review integrated relevant studies on upstream regulation and downstream signals of Amot family members, as well as the latest progress in physiological and pathological functions and clinical applications, hoping to offer important ideas for further research.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099588 | PMC |
| http://dx.doi.org/10.3892/etm.2024.12546 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!