AI Article Synopsis
- The study focuses on the specific carbohydrate (SCC) produced by the bacteria that cause dental caries, which is essential for their survival.
- SCC features a structure made of a polyrhamnose backbone with glucose side-chains and glycerol phosphate decorations, and the research identifies one major and two minor glucose modifications on this carbohydrate.
- The major glucose modification is crucial for biofilm formation and is created by specific enzymes, while both major and minor modifications affect the shape of the bacteria.
Article Abstract
the causative agent of human dental caries, expresses a cell wall attached Serotype specific Carbohydrate (SCC) that is critical for cell viability. SCC consists of a repeating →3)α-Rha(1→2)α-Rha(1→ polyrhamnose backbone, with glucose (Glc) side-chains and glycerol phosphate (GroP) decorations. This study reveals that SCC has one major and two minor Glc modifications. The major Glc modification, α-Glc, attached to position 2 of 3-rhamnose, is installed by SccN and SccM glycosyltransferases and is the site of the GroP addition. The minor Glc modifications are β-Glc linked to position 4 of 3-rhamnose installed by SccP and SccQ glycosyltransferases, and α-Glc attached to position 4 of 2-rhamnose installed by SccN working in tandem with an unknown enzyme. Both the major and the minor β-Glc modifications control bacterial morphology, but only the GroP and major Glc modifications are critical for biofilm formation.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100793 | PMC |
| http://dx.doi.org/10.1101/2024.05.09.593426 | DOI Listing |
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