Exposure to an aversive odor alters physiology.

Perception of external cues is important for enhancing the fitness and survival of animals. However, the role of odor perception in regulation of longevity and health is incompletely defined. Here, we show that the exposure to an aversive odor 2-nonanone reduces life span, brood size, feeding rate, and increases lipid storage in worms. These effects are restored to normal levels in mutant worms lacking functional olfactory AWB neurons, suggesting a potential role of odor perception in the regulation of animal physiology and longevity.