AI Article Synopsis
- - Malignant peritoneal mesothelioma is a very rare cancer in children, as shown by a case of a 5-year-old boy who had a large abdominal mass that was surgically removed.
- - After surgery, tests confirmed the diagnosis, but comprehensive genomic profiling showed no major mutations, though some gene amplifications were noted.
- - The boy later developed metastatic disease and unfortunately passed away from pneumonia, highlighting the poor prognosis and limited treatment options for pediatric peritoneal mesothelioma, as well as the need for more research on potential biomarkers.
Article Abstract
Malignant peritoneal mesothelioma is an extremely rare and poorly recognized neoplasm in children. A 5-year-old boy presented with a 1-year history of progressive painless abdominal distension. A CT revealed a 19 × 19 × 11 cm cystic mass in the right hemiabdomen, without infiltrating the surrounding structures. The tumor was completely removed by surgery. The microscopic and immunohistochemical analyses confirmed peritoneal mesothelioma. Comprehensive genomic profiling revealed no major driving mutations including , no fusions, but with amplifications of and genes. Imaging follow-up 3 months after surgery revealed metastatic disease. The patient died of pneumonia at another hospital shortly after the last follow-up examination at our institution. Pediatric peritoneal mesothelioma is an extremely rare malignancy with limited targeted options and a poor prognosis. Some of the identified molecular genomic biomarkers require further exploration and validation in this cancer.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102791 | PMC |
| http://dx.doi.org/10.1093/jscr/rjae324 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analysis of TERT mRNA Levels and Clinicopathological Features in Patients with Peritoneal Mesothelioma.
Cancers (Basel)
January 2025
Department of Medicine and Surgery, LUM University, Casamassima, 70010 Bari, Italy.
Background/objectives: Telomerase reverse transcriptase (TERT) is the catalytic subunit of the telomerase enzyme responsible for telomere length maintenance and is an important cancer hallmark. Our study aimed to clarify the mRNA expression of TERT in peritoneal mesothelioma (PeM), and to explore the relationship between its expression and the clinicopathological parameters and prognosis of patients with PeM.
Methods: In a cohort of 13 MpeM patients, we evaluated histotype, nuclear grade, mitotic count, necrosis, inflammation, Ki67, BAP1, MTAP and p16 expression by immunohistochemistry, / status by FISH and TERT mRNA expression by RNAscope.
A Rare Case of Peritoneal Mesothelioma Detected by 18F-AlF-NOTA-Octreotide PET/CT.
Clin Nucl Med
January 2025
From the Department of Nuclear Medicine (PET-CT Center), National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
We present a case of 37-year-old man with multiple masses in the abdominal and pelvic cavity who underwent 18F-AlF-NOTA-octreotide PET/CT. The masses demonstrated heterogeneously increased uptake on 18F-AlF-NOTA-octreotide PET/CT and were suggestive of neuroendocrine tumor. However, the histopathological examinations confirmed the masses to be peritoneal mesothelioma.
View Article and Find Full Text PDF68Ga-FAPI PET/CT Depicted Non-FDG-Avid Malignant Peritoneal Mesothelioma.
Clin Nucl Med
January 2025
Department of Ultrasound, The Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan, China.
Malignant peritoneal mesothelioma (MPM) is a rare and aggressive malignancy of mesothelial cells in the peritoneum. Herein, we describe the 68Ga-FAPI and 18F-FDG PET/CT findings of MPM in a 41-year-old man. In the present case, the primary and metastatic tumors showed intense 68Ga-FAPI accumulation but no significantly increased 18F-FDG uptake.
View Article and Find Full Text PDFPredicting Postoperative Infection After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy with Splenectomy.
Ann Surg Oncol
January 2025
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Hematologic changes after splenectomy and hyperthermic intraperitoneal chemotherapy (HIPEC) can complicate postoperative assessment of infection. This study aimed to develop a machine-learning model to predict postoperative infection after cytoreductive surgery (CRS) and HIPEC with splenectomy.
Methods: The study enrolled patients in the national TriNetX database and at the Johns Hopkins Hospital (JHH) who underwent splenectomy during CRS/HIPEC from 2010 to 2024.
Surgical and oncological outcome after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma : A retrospective single center experience.
Wien Klin Wochenschr
January 2025
Saidu Medical College Swat, Saidu Sharif, Pakistan.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!