AI Article Synopsis
- A new cosolvent system using dichloromethane (DCM) and heptafluoropropyl methyl ether (HFPME) was developed to dissolve both FDC and a special polymer (FPI), allowing for effective emulsification.
- The resulting FDC-encapsulated FPI microparticles demonstrated good performance in oxygen supply, along with traits like uniformity, stability, and compatibility for biomedical applications.
Article Abstract
Red blood cell-inspired perfluorocarbon-encapsulated core-shell particles have been developed for biomedical applications. Although the use of perfluorodecalin (FDC) is expected for core-shell particles owing to its high oxygen solubility, the low solubility of FDC in any organic solvent, owing to its fluorous properties, prevents its use in core-shell particles. In this study, a new cosolvent system composed of dichloromethane (DCM) and heptafluoropropyl methyl ether (HFPME) was found to dissolve both FDC and fluorinated polyimide (FPI) based on a systematic study using a phase diagram, achieving a homogeneous disperse phase for emulsification composed of oxygen-permeable FPI and oxygen-soluble FDC. Using this novel cosolvent system and Shirasu porous glass (SPG) membrane emulsification, FDC-encapsulated FPI shell microparticles were successfully prepared for the first time. In addition to oxygenation, demonstrated using hypoxia-responsive HeLa cells, the fabricated core-shell microparticles exhibited monodispersity, excellent stability, biocompatibility, and oxygen capacity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097379 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c00897 | DOI Listing |
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