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Molecular approaches to mammalian uterine receptivity for conceptus implantation. | LitMetric

Molecular approaches to mammalian uterine receptivity for conceptus implantation.

J Reprod Dev

Division of Advanced Feeding Technology Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tochigi 329-2793, Japan.

Published: August 2024

AI Article Synopsis

Article Abstract

Mammalian reproduction is more inefficient than expected and embryo/conceptus implantation into the maternal endometrium is considered to be a rate-limiting process. Although extensive physiological and structural diversity exists among mammalian species, the basic molecular mechanisms underlying successful implantation are conserved. The extensive use of genetically engineered mouse models has provided considerable information on uterine receptivity for embryo implantation. The molecular mechanisms and cellular processes identified thus far require further validation in other mammalian species. In this review, representative ovarian steroid hormone-induced signaling pathways controlling uterine adaptation are presented based on the results of rodent studies. Selected examples of functional conservation in mammals, such as humans and cattle, are briefly described. To date, molecular therapeutic trials for fertility improvement have not been conducted. Considerable efforts are required to provide further understanding of these molecular mechanisms. Such understanding will contribute to the development of reliable clinical diagnostics and therapeutics for implantation failure, leading to reproductive success in a wide variety of mammals in the future.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11310385PMC
http://dx.doi.org/10.1262/jrd.2024-022DOI Listing

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