A 45 years old woman, hemodialysed since 1981, with an history of Staphylococcal septicemia in may 1983, is admitted in emergency room in may 1984 for massive gastro intestinal bleeding. After oesogastro fibroscopy suspecting duodenal ulcer, because continuous and recurrent bleeding, a laparotomy find only symptoms of portal hypertension (ascites, venous dilatation on abdominal oesophagus and stomach). The ligation of this venous dilatations stop temporarily the gastro intestinal bleeding. But recurrence of this bleeding conduct to a celiac angiography discovering a splenic aneurysm with arterio venous fistula. The surgical treatment of this aneurysm can stop the gastro intestinal bleeding. Histopathologic observation of this aneurysm can suspect an infectious origin.
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J Exp Biol
January 2025
Department of Biological Sciences, University of Alberta, 116 St and 85 Ave, Edmonton, AB T6G 2R3, Canada.
Acidification is a key component of digestion throughout metazoans. The gut digestive fluid of many invertebrates is acidified by the vesicular-type H+-ATPase (VHA). In contrast, vertebrates generate acidic gut fluids using the gastric H+/K+-ATPase (HKA); an evolutionary innovation linked with the appearance of a true stomach that greatly improves digestion, absorption, and immune function.
View Article and Find Full Text PDFIndian J Endocrinol Metab
December 2024
Department of Endocrinology, Max Super Speciality Hospital, Saket, New Delhi, India.
Introduction: Oral Semaglutide (Sema-o) is the first oral glucagon like peptide-1 receptor analogue (GLP-1RA) commercially available for the treatment of type 2 diabetes (T2D). This study aimed to evaluate the efficacy of Sema-o in patients with T2D when added to the existing therapy.
Methods: This retrospective real-world study enrolled adult patients with diabetes taking Sema-o, with at least one follow-up (from February 2022 till October 2023).
J Pharm Sci
January 2025
Department of Synthetic Molecule Pharmaceutical Sciences, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address:
It is desirable but remains challenging to develop high drug load amorphous solid dispersions (ASDs) without compromising their quality attributes and bio-performance. In this work, we investigated the impacts of formulation variables, such as drug loading (DL) and polymer type, on dissolution behavior, diffusive flux, and in vitro drug absorption of ASDs of a high T compound, GDC-6893. ASDs with two polymers (HPMCAS and PVPVA) and various DLs (20 - 80%) were produced by spray drying and their drug-polymer miscibility was evaluated using solid-state nuclear magnetic resonance (ssNMR).
View Article and Find Full Text PDFVet Res Commun
January 2025
Faculdade de Ciências Agrárias, Universidade Federal da Grande Dourados, Rodovia Dourados - Itahum, km 12, Cidade Universitária, Dourados, MS, Brasil.
Aflatoxin is a mycotoxin produced by fungi of the genus Aspergillus that is present in various foods. Probiotics are well-established products in aquaculture, and due to their effective contribution to the intestine, they can be used as an aflatoxin adsorbent. This study evaluated the effects of aflatoxin B1 (AFB1) on enzymatic activity and intestinal function in Piaractus mesopotamicus (pacu) fingerlings fed diets containing a probiotic-based adsorbent (PBA).
View Article and Find Full Text PDFGastro Hep Adv
September 2024
European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK.
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