AI Article Synopsis
- Fungal infections in neonatal intensive care units (NICUs) are primarily caused by Candida species, leading to high mortality, and can spread through healthcare professionals’ hands despite hygiene efforts.
- A study identified and tested various Candida species from healthcare workers' hands before and after using 70% ethanol-based gel, examining their virulence factors and antifungal resistance.
- The research found that C. parapsilosis complex was the most common species, and several strains showed resistance to common antifungals like amphotericin B and fluconazole, emphasizing the need for improved infection control measures in hospitals.
Article Abstract
Fungal infections in neonatal intensive care units (NICU) are mainly related to Candida species, with high mortality rates. They are predominantly of endogenous origin, however, cross-infection transmitted by healthcare professionals' hands has occurred. The aim of this study was to identify Candida species isolated from the hands of healthcare professionals in a NICU before and after hygiene with 70% ethanol-based gel and evaluate virulence factors DNase, phospholipase, proteinase, hemolysin, biofilm biomass production, and metabolic activity. In vitro antifungal susceptibility testing and similarity by random amplified polymorphic DNA (RAPD) were also performed. C. parapsilosis complex was the most frequent species (57.1%); all isolates presented at least one virulence factor; three isolates (Candida parapsilosis complex) were resistant to amphotericin B, two (Candida famata [currently Debaryomyces hansenii] and Candida guilliermondii [currently Meyerozyma guilliermondii]) was resistant to micafungin, and six (Candida parapsilosis complex, Candida guilliermondii [=Meyerozyma guilliermondii], Candida viswanathi, Candida catenulata [currently Diutina catenulata] and Candida lusitaniae [currently Clavispora lusitaniae]) were resistant to fluconazole. Molecular analysis by RAPD revealed two clusters of identical strains that were in the hands of distinct professionals. Candida spp. were isolated even after hygiene with 70% ethanol-based gel, highlighting the importance of stricter basic measures for hospital infection control to prevent nosocomial transmission.
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| http://dx.doi.org/10.1016/j.mycmed.2024.101482 | DOI Listing |
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