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SMURF1 mediates damaged lysosomal homeostasis by ubiquitinating PPP3CB to promote the activation of TFEB.
Autophagy
October 2024
Department of General Surgery, Aerospace Center Hospital, School of Life Science, Beijing Institute of Technology, Beijing, China.
The calcium-activated phosphatase PPP3/calcineurin dephosphorylates TFEB (transcription factor EB) to trigger its nuclear translocation and the activation of macroautophagic/autophagic targets. However, the detailed molecular mechanism regulating TFEB activation remains poorly understood. Here, we highlighted the importance of SMURF1 (SMAD specific E3 ubiquitin protein ligase 1) in the activation of TFEB for lysosomal homeostasis.
View Article and Find Full Text PDFPediatric reference values of NT-proBNP and Galectin-3 based on a French cohort.
Clin Chim Acta
January 2025
Department of Pediatric Cardiac Surgery, AP-HP, Necker-Enfants Malades Hospital, Paris, France; Pediatric Cardiology Unit, Women and Child Department, Lausanne University Hospital, Lausanne, Switzerland. Electronic address:
Background: In pediatric cardiology, the fact that some new biomarkers have assay-specific normal values has to be considered for correct clinical decisions. The current study aimed to provide age-adjusted normative values for NT-proBNP and Galectin-3 using the Abbott immunoassay system from a prospective French pediatric cohort sera collection and to validate our data for NT-proBNP on a second retrospective cohort.
Methods: We analyzed 283 consecutive samples for NT-proBNP and 140 samples for Galectin-3 collected from apparently healthy children (0-18 years) with outpatient treatment at our institution (Hôpital Necker-Enfants malades, Paris, France) during 24 months.
Correction to: Galectin-3 levels in children with cystic fibrosis.
Eur J Pediatr
August 2024
Department of Pediatric Pulmonology, School of Medicine, Hacettepe University, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.
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