AI Article Synopsis
- - Human brain organoid models are valuable for researching brain development and function due to their ability to mimic human genetics and facilitate lab manipulation.
- - There are ongoing concerns about the accuracy and reliability of these models, which need to be addressed to maximize their potential in science and medicine.
- - The article reviews current techniques for analyzing these organoids, discusses existing challenges, and offers suggestions for improving consistency and precision in future research.
Article Abstract
Human brain organoid models have emerged as a promising tool for studying human brain development and function. These models preserve human genetics and recapitulate some aspects of human brain development, while facilitating manipulation in an in vitro setting. Despite their potential to transform biology and medicine, concerns persist about their fidelity. To fully harness their potential, it is imperative to establish reliable analytic methods, ensuring rigor and reproducibility. Here, we review current analytical platforms used to characterize human forebrain cortical organoids, highlight challenges, and propose recommendations for future studies to achieve greater precision and uniformity across laboratories.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297560 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2024.04.008 | DOI Listing |
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