AI Article Synopsis

  • Hemangiosarcoma in dogs and angiosarcoma in humans are aggressive sarcomas originating from blood vessel-forming cells, characterized by disorganized vascular spaces and high metastasis rates.
  • The study used dog-in-mouse xenografts to mimic the tumors' properties, observing the complex interaction between donor and host cells, which led to the development of myeloid hyperplasia and lymphoproliferative tumors.
  • Findings suggest that these sarcomas create a supportive microenvironment for hematopoietic (blood cell) growth, indicating a potential role in tumor progression by regulating surrounding stromal and immune responses.

Article Abstract

Unlabelled: Hemangiosarcoma and angiosarcoma are soft-tissue sarcomas of blood vessel-forming cells in dogs and humans, respectively. These vasoformative sarcomas are aggressive and highly metastatic, with disorganized, irregular blood-filled vascular spaces. Our objective was to define molecular programs which support the niche that enables progression of canine hemangiosarcoma and human angiosarcoma. Dog-in-mouse hemangiosarcoma xenografts recapitulated the vasoformative and highly angiogenic morphology and molecular characteristics of primary tumors. Blood vessels in the tumors were complex and disorganized, and they were lined by both donor and host cells. In a series of xenografts, we observed that the transplanted hemangiosarcoma cells created exuberant myeloid hyperplasia and gave rise to lymphoproliferative tumors of mouse origin. Our functional analyses indicate that hemangiosarcoma cells generate a microenvironment that supports expansion and differentiation of hematopoietic progenitor populations. Furthermore, gene expression profiling data revealed hemangiosarcoma cells expressed a repertoire of hematopoietic cytokines capable of regulating the surrounding stromal cells. We conclude that canine hemangiosarcomas, and possibly human angiosarcomas, maintain molecular properties that provide hematopoietic support and facilitate stromal reactions, suggesting their potential involvement in promoting the growth of hematopoietic tumors.

Significance: We demonstrate that hemangiosarcomas regulate molecular programs supporting hematopoietic expansion and differentiation, providing insights into their potential roles in creating a permissive stromal-immune environment for tumor progression.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11166094PMC
http://dx.doi.org/10.1158/2767-9764.CRC-23-0441DOI Listing

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