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Liquid-Gas Phase Transition Actuator: Rejuvenation Procedure Extended and Open-Air Performance.
Polymers (Basel)
December 2024
Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences (ISPM RAS), Profsoyuznaya Str. 70, 117393 Moscow, Russia.
To achieve the actuation of silicone-based foamed composites, a liquid-gas phase transition of the liquid captured in its pores is employed. The uncertainty of key parameters for a single or sequential open-air performance of such soft actuators limits their application. To define the main characteristics of the composites, in this work, two functions of the liquid there were separated: the pore-forming agent (FPA) and working liquid (WL).
View Article and Find Full Text PDFTranscriptome Analysis Reveals the Mechanism of Y0-C10-HSL on Biofilm Formation and Motility of .
Pharmaceuticals (Basel)
December 2024
School of Biological & Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China.
() is a type of pathogen that takes advantage of opportunities to infect and form biofilm during infection. Inhibiting biofilm formation is a promising approach for the treatment of biofilm-related infections. Here, Y0-C10-HSL (N-cyclopentyl-n-decanamide) was designed, synthesized, and tested for its effect on biofilm formation, motility, and the () survival assay.
View Article and Find Full Text PDFPA-Win2: In Silico-Based Discovery of a Novel Peptide with Dual Antibacterial and Anti-Biofilm Activity.
Antibiotics (Basel)
November 2024
Department of Life Science, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Article Synopsis
- The rise of antibiotic-resistant bacteria (ARBs) poses a significant global health threat due to increasing infections and mortality rates.
- The study focused on using a deep-learning model to identify antimicrobial peptides (AMPs) from spider venom, with a promising candidate, PA-Win2, showing strong effectiveness against multidrug-resistant strains.
- PA-Win2 not only inhibited bacterial growth and biofilm formation but also altered gene expression linked to bacterial survival, suggesting its potential as a new treatment for ARB infections.
Bridging the Gap: Advances and Challenges in Heart Regeneration from In Vitro to In Vivo Applications.
Bioengineering (Basel)
September 2024
Department of Surgery, Ohio State University, Columbus, OH 43210, USA.
Cardiovascular diseases, particularly ischemic heart disease, area leading cause of morbidity and mortality worldwide. Myocardial infarction (MI) results in extensive cardiomyocyte loss, inflammation, extracellular matrix (ECM) degradation, fibrosis, and ultimately, adverse ventricular remodeling associated with impaired heart function. While heart transplantation is the only definitive treatment for end-stage heart failure, donor organ scarcity necessitates the development of alternative therapies.
View Article and Find Full Text PDFOptimal Preservation of PFFs in Glycerol Enhances Suitability for Modeling Parkinson's Disease.
Small
December 2024
Department of Neurology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Injecting α-synuclein pre-formed fibrils (αSyn PFFs) into various tissues and organs involves converting monomeric αSyn into a fibrillar form, inducing extensive αSyn pathology that effectively models Parkinson's disease (PD). However, the distinct physicochemical properties of αSyn amyloid fibrils can potentially reduce their seeding activity, especially during storage. In this study, it is demonstrated that αSyn PFFs exhibit significant sensitivity to low temperatures, with notable denaturation occurring between -20 and 4 °C, and gradual disassembly persisted even under storage conditions at -80 °C.
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