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Mechanisms of epigallocatechin gallate (EGCG) in ameliorating hyperuricemia: insights into gut microbiota and intestinal function in a mouse model. | LitMetric

AI Article Synopsis

  • Epigallocatechin gallate (EGCG), a key compound in tea, shows potential in reducing high uric acid levels (hyperuricemia) in mice, comparable to the medication allopurinol.
  • The study found that EGCG decreases uric acid levels by enhancing kidney gene expression that promotes uric acid secretion while inhibiting its reabsorption.
  • Additionally, EGCG alters gut microbiota composition and influences gene expression in the intestines, suggesting that both gut bacteria and metabolic changes play a role in its health benefits.

Article Abstract

Epigallocatechin gallate (EGCG), a prominent bioactive compound found in tea, offers numerous health benefits. Previous studies have highlighted its potential in mitigating hyperuricemia. In this study, hyperuricemic mice induced by potassium oxonate (PO) were treated with EGCG or the anti-hyperuricemia medication allopurinol (AP) to investigate the mechanisms underlying their anti-hyperuricemic effects. The results demonstrated that both EGCG and AP significantly reduced serum uric acid (UA) levels. Further analysis revealed that EGCG promoted the expression of UA secretion transporter genes ( and ) while inhibiting the expression of UA reabsorption transporter genes ( and ) in the kidney. By 16S rDNA sequencing, EGCG, but not AP, was found to alter the composition of the gut microbiota. Notably, EGCG induced significant changes in the relative abundance of specific bacteria such as , , and , which displayed high correlations with serum UA levels and UA-related gene expression. Metabolomic analysis suggested that EGCG-induced modifications in bacterial metabolites might contribute to the alleviation of hyperuricemia. Transcriptomic analysis of the intestinal epithelium identifies 191 differentially expressed genes (DEGs) in EGCG-treated mice, including 8 purine-related genes. This study elucidates the anti-hyperuricemic mechanisms of EGCG, particularly its influence on the gut microbiota and gene expression in the intestinal epithelium.

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Source
http://dx.doi.org/10.1039/d4fo01606hDOI Listing

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