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Impact of treatment and clinical characteristics on the survival of children with medulloblastoma in Mexico. | LitMetric

AI Article Synopsis

Article Abstract

Introduction: Data on medulloblastoma outcomes and experiences in low- and middle-income countries, especially in Latin America, is limited. This study examines challenges in Mexico's healthcare system, focusing on assessing outcomes for children with medulloblastoma in a tertiary care setting.

Methods: A retrospective analysis was conducted, involving 284 patients treated at 21 pediatric oncology centers in Mexico.

Results: High-risk patients exhibited markedly lower event-free survival than standard-risk patients (43.5% vs. 78.3%, p<0.001). Influential factors on survival included anaplastic subtype (HR 2.4, p=0.003), metastatic disease (HR 1.9, p=0.001); residual tumor >1.5cm², and lower radiotherapy doses significantly impacted event-free survival (EFS) and overall survival (OS). Platinum-based chemotherapy showed better results compared to the ICE protocol in terms of OS and EFS, which was associated with higher toxicity. Patients under 3 years old displayed notably lower OS and EFS compared to older children (36.1% vs. 55.9%, p=0.01).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096484PMC
http://dx.doi.org/10.3389/fonc.2024.1376574DOI Listing

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