Collagenous gastritis is a rare and chronic inflammatory condition of undetermined etiology characterized histologically by thickened subepithelial collagen bands and increased intraepithelial lymphocytes. Here, we present a collagenous gastritis case in a 16-year-old female with chronic abdominal pain, persistently elevated fecal calprotectin (507 and 796 mcg/g), and resolved iron deficiency anemia. The patient's history, laboratory tests, endoscopy, and magnetic resonance imaging ruled out common causes of elevated fecal calprotectin, including and gastrointestinal infections, medications, celiac disease, and inflammatory bowel disease, as well as less common causes such as collagenous . Esophagogastroduodenoscopy revealed significant antral nodularity. Gastric biopsies showed thickened subepithelial collagen band and surface epithelium damage with increased intraepithelial lymphocytes. The ileocolonoscopy was normal. This is among the first reported cases of collagenous gastritis with elevated fecal calprotectin levels that could solely be attributed to this condition.
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| http://dx.doi.org/10.1002/jpr3.12055 | DOI Listing |
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Article Synopsis
- Collagenous gastritis (CG) and Lymphocytic gastritis (LG) are uncommon forms of gastritis characterized by specific cellular changes, and this study aimed to analyze their prevalence and features in children over a 23-year period.
- In a review of 31 pediatric cases, CG was found in 11 patients (35.5%), while LG was identified in 20 patients (64.5%), most of whom presented with gastrointestinal symptoms and iron deficiency anemia.
- Treatment typically involved iron supplements, proton pump inhibitors, and dietary changes, with most patients showing improvement in hemoglobin levels, although some required ongoing treatment and a follow-up endoscopy showed no significant histopathological changes
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