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| http://dx.doi.org/10.1038/s41423-024-01159-5 | DOI Listing |
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Chemerin attenuates acute kidney injury by inhibiting ferroptosis via the AMPK/NRF2/SLC7A11 axis.
Commun Biol
December 2024
Department of Nephrology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, 226001, Jiangsu, China.
Acute kidney injury (AKI) is a common and life-threatening condition associated with cell death, where ferroptosis plays a critical role. Chemerin, primarily produced in white adipose tissue, has multiple biological functions in renal pathophysiology. However, to date, whether and how chemerin regulates the progression of AKI remain unclear.
View Article and Find Full Text PDFChemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet.
Mol Med
November 2024
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Article Synopsis
- High glucose levels in gestational diabetes mellitus (GDM) lead to oxidative stress in the placenta, which is critical for the development of the condition.
- The study explored the effects of the adipokine chemerin on oxidative stress in placental cells and established a GDM animal model to assess its impacts in vivo.
- Results showed that chemerin can reduce oxidative stress markers, improve antioxidant capacity, and lower blood glucose levels in pregnant mice with GDM, highlighting its potential therapeutic role.
A Cross-Sectional Study: Systematic Quantification of Chemerin in Human Cerebrospinal Fluid.
Biomedicines
November 2024
Department of Neurology, University of Giessen, Klinikstr. 33, 35392 Giessen, Germany.
Background: Dysregulation of adipokines is considered a key mechanism of chronic inflammation in metabolic syndrome. Some adipokines affect food intake by crossing the blood/brain barrier. The adipokine chemerin is associated with metabolic syndrome, cardiovascular diseases and immune response.
View Article and Find Full Text PDFStructural Basis for Chemerin Recognition and Signaling Through Its Receptors.
Biomedicines
October 2024
Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.
Chemerin is a chemotactic adipokine that participates in a multitude of physiological processes, including adipogenesis, leukocyte chemotaxis, and neuroinflammation. Chemerin exerts biological functions through binding to one or more of its G protein-coupled receptors (GPCRs), namely chemokine-like receptor 1 (CMKLR1), G protein-coupled receptor 1 (GPR1), and CC-motif receptor-like 2 (CCRL2). Of these receptors, CMKLR1 and GPR1 have been confirmed as signaling receptors of chemerin, whereas CCRL2 serves as a chemerin-binding protein without transmembrane signaling.
View Article and Find Full Text PDFAdipokines and their potential impacts on susceptibility to myocardial ischemia/reperfusion injury in diabetes.
Lipids Health Dis
November 2024
Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macao, PR, China.
Article Synopsis
- Coronary artery disease poses a significant public health risk, with myocardial ischemia often requiring immediate treatments like thrombolytic therapy to restore blood flow; however, this can lead to additional damage known as ischemia/reperfusion (I/R) injury.
- Diabetes increases the heart's susceptibility to I/R injury due to issues with metabolism and heightened inflammatory responses, making the roles of adipokines crucial in this context.
- The review explores recent findings on various adipokines, some of which offer protective effects against heart damage in conditions like obesity and diabetes, while others may worsen inflammation and damage, underscoring the need for further research in this area.
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