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Synthesis of carboxymethyl chitosan-guar gum-poly(vinylpyrrolidone) ternary blended hydrogels with antibacterial/anticancer efficacy and drug delivery applications. | LitMetric

AI Article Synopsis

  • * This study focused on creating hydrogel blends using carboxymethyl chitosan, guar gum, and poly(vinylpyrrolidone) through ionizing irradiation, bypassing harmful chemical agents.
  • * The resulting hydrogels showed great swelling properties, high cell viability in compatibility tests, antibacterial effectiveness, and over 80% release of anti-inflammatory drugs, making them promising for various biomedical applications.

Article Abstract

Biopolymers have the utmost significance in biomedical applications and blending synthetic polymers has shown favorable characteristics versus individual counterparts. The utilization of the blends can be restricted through the use of toxic chemical agents such as initiators or crosslinkers. In this regard, a chemical agent-free ionizing irradiation is a beneficial alternative for preparing the hydrogels for biomedical applications. In this study, carboxymethyl chitosan (CM-CS), guar gum (GG), and poly(vinylpyrrolidone) (PVP) based ternary blends (TB) were crosslinked using various doses of ionizing irradiation to fabricate hydrogels. The prepared hydrogels were characterized for physicochemical properties, swelling analysis, biological assays, and drug delivery applications. Swelling analysis in distilled water revealed that the hydrogels exhibit excellent swelling characteristics. An cytocompatibility assay showed that the hydrogels have greater than 90% cell viability for the human epithelial cell line and a decreasing cell viability trend for the human alveolar adenocarcinoma cell line. In addition, the prepared hydrogels possessed excellent antibacterial characteristics against gram-positive () and gram-negative (). Finally, the release studies of anti-inflammatory (QA) loaded hydrogels exhibited more than 80% release in phosphate-buffered saline (pH = 7.4). These findings suggest that TB hydrogels can be used as suitable carrier media for different release systems and biomedical applications.

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Source
http://dx.doi.org/10.1080/09205063.2024.2349409DOI Listing

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