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Mix and Shake: A Mild Way to Drug-Loaded Lysozyme Nanoparticles. | LitMetric

AI Article Synopsis

  • Biocompatible nanoparticles made from lysozyme and fructose improve the delivery and effectiveness of hydrophobic drugs like curcumin, ellipticine, and dasatinib.
  • A new method creates stable, drug-loaded nanoparticles about 150 nm in size, which are less toxic and require less complex synthesis than traditional methods.
  • The study indicates that lysozyme-enhanced dual-drug particles significantly boost cytotoxicity and drug uptake in various cancer cells, offering a promising strategy for drug delivery.

Article Abstract

Biocompatible nanoparticles as drug carriers can improve the therapeutic efficiency of hydrophobic drugs. However, the synthesis of biocompatible and biodegradable polymeric nanoparticles can be time-consuming and often involves toxic solvents. Here, a simple method for protein-based stable drug-loaded particles with a narrow polydispersity is introduced. In this process, lysozyme is mixed with hydrophobic drugs (curcumin, ellipticine, and dasatinib) and fructose to prepare lysozyme-based drug particles of around 150 nm in size. Fructose is mixed with the drug to generate nanoparticles that serve as templates for the lysozyme coating. The effect of lysozyme on the physicochemical properties of these nanoparticles is studied by transmission electron microscopy (TEM) and scattering techniques (e.g., dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS)). We observed that lysozyme significantly stabilized the curcumin fructose particles for 7 days. Moreover, additional drugs, such as ellipticine and dasatinib, can be loaded to form dual-drug particles with narrow polydispersity and spherical morphology. The results also reveal that lysozyme dual ellipticine/dasatinib curcumin particles enhance the cytotoxicity and uptake on MCF-7 cells, RAW 264.7 cells, and U-87 MG cells due to the larger and rigid hydrophobic core. In summary, lysozyme in combination with fructose and curcumin can serve as a powerful combination to form protein-based stable particles for the delivery of hydrophobic drugs.

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Source
http://dx.doi.org/10.1021/acsami.4c05497DOI Listing

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