Acquired methemoglobinemia (MetHb) is a rare but potentially life-threatening condition that has varied etiology, usually toxin- or drug-induced. We had five cases of acquired methemoglobinemia during six months. Their presentation varied from an asymptomatic state to respiratory distress. The presence of cyanosis and low oxygen saturation (SpO), despite normal partial pressure of oxygen (PaO) and chocolate brown-colored blood, were diagnostic clues present in all cases. A high level of methemoglobinemia was detected on arterial blood gas (ABG), confirming the diagnosis. Methylene blue was used as an antidote along with supportive care in symptomatic cases. All these cases of methemoglobinemia recovered completely. A high index of suspicion for methemoglobinemia should be maintained in cases presenting with persistent hypoxia or cyanosis despite normal PaO.
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http://dx.doi.org/10.7759/cureus.58312 | DOI Listing |
Pan Afr Med J
December 2024
Al Jalila Children's Hospital, Dubai Health, Dubai, United Arab Emirates.
Methemoglobinemia (MetHb) is a life-threatening condition that reduces the oxygen-carrying ability of hemoglobin. Acquired methemoglobinemia usually results from exposure to specific oxidizing agents. Symptoms and complications depend on the MetHb level, which can sometimes be fatal.
View Article and Find Full Text PDFCureus
November 2024
Department of Anesthesiology and Intensive Care, Celal Bayar University Training and Research Hospital, Manisa, TUR.
Methemoglobinemia is a rare but potentially life-threatening condition in which hemoglobin is oxidized, impairing the oxygen-carrying capacity. While congenital forms exist, acquired methemoglobinemia can occur in perioperative settings, especially following exposure to oxidizing agents such as dyes used in sentinel lymph node biopsy (SLNB). Patent Blue V, a synthetic aniline dye commonly used for SLNB, has been associated with rare but serious adverse effects, including methemoglobinemia.
View Article and Find Full Text PDFBMJ Case Rep
December 2024
Neonatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamilnadu, India.
Eur J Case Rep Intern Med
September 2024
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mount Lebanon Hospital Balamand University Medical Center, Beirut, Lebanon.
Proc Natl Acad Sci U S A
October 2024
Department of Environment Science, College of Environment and Resource, Research Center of Environment and Health, Shanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Shanxi University, Taiyuan, Shanxi 030006, People's Republic of China.
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