A new polyene macrolide, machidamycin (1), and a known compound YS-822A (2), were obtained by physicochemical screening from a culture broth of Streptomyces sp. K22-0017. The structures were elucidated using MS and 1D/2D NMR analyses. Compound 1 exhibited weak antifungal activity against Candida albicans and Mucor racemosus. Furthermore, 1 showed stronger antileishmanial activity than the existing drug paromomycin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41429-024-00737-z | DOI Listing |
Publication Analysis
Top Keywords
polyene macrolide
8
streptomyces k22-0017
8
macrolide antibiotic
4
antibiotic machidamycin
4
machidamycin produced
4
produced streptomyces
4
k22-0017 polyene
4
macrolide machidamycin
4
machidamycin compound
4
compound ys-822a
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!