AI Article Synopsis
- X-linked agammaglobulinemia (XLA) increases the risk of gastrointestinal cancers, notably gastric cancer (GC), as seen in a 30-year-old male patient.
- The patient was diagnosed with GC and extensive atrophic gastritis, testing positive for Helicobacter pylori through a urea breath test.
- Despite successful distal gastrectomy and chemotherapy, he passed away two years later, highlighting the need for regular evaluations for H. pylori and monitoring for GC in XLA patients due to their immunoglobulin deficiency.
Article Abstract
X-linked agammaglobulinemia (XLA) is associated with an increased risk of gastrointestinal cancers including gastric cancer (GC). We herein report the case of a 30-year-old male patient with XLA who developed GC and extensive atrophic gastritis. He tested positive in the urea breath test, thus indicating the presence of Helicobacter pylori. Distal gastrectomy and chemotherapy were performed without any complications; however, the died two years after this diagnosis. Immunoglobulin deficiency makes these patients susceptible to progressive atrophic gastritis and the associated risk of GC. Therefore, patients with XLA are advised to undergo an evaluation for Helicobacter pylori infection as well as monitoring for GC.
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| http://dx.doi.org/10.2169/internalmedicine.3236-23 | DOI Listing |
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