Proton pump inhibitors: seeking the golden ratio between gastroprotection and cardiovascular risk.

Eur Heart J Cardiovasc Pharmacother

Cardiology Department, Athens Naval Hospital, 70 Dinokratous Street, 11521 Athens, Greece.

Published: August 2024

Download full-text PDF

Source
http://dx.doi.org/10.1093/ehjcvp/pvae037DOI Listing

Publication Analysis

Top Keywords

proton pump
4
pump inhibitors
4
inhibitors seeking
4
seeking golden
4
golden ratio
4
ratio gastroprotection
4
gastroprotection cardiovascular
4
cardiovascular risk
4
proton
1
inhibitors
1

Similar Publications

Phylogenetic position of the subfamily Symphrasinae (Insecta: Neuroptera), its intergeneric relationships and evolution of the raptorial condition within Mantispoidea.

Invertebr Syst

January 2025

Instituto de Biología, UNAM, Departamento de Zoología, Colección Nacional de Insectos, Apartado Postal 70-153, 04510, Ciudad de México, Mexico.

The superfamily Mantispoidea (Insecta: Neuroptera) includes the families Berothidae, Rhachiberothidae and Mantispidae. Among these taxa, the last two are collectively known as Raptorial Mantispoidea due to the presence of grasping forelegs for predatory habits. The Mantispidae classically included the subfamilies Symphrasinae, Drepanicinae, Calomantispinae and Mantispinae, yet recent research challenged this classification scheme as well as the monophyly of this family resulting in Symphrasinae being transferred to Rhachiberothidae.

View Article and Find Full Text PDF

Molecular evidence of (Pallas, 1781) in cockchafers in rural areas of Elazig, Türkiye.

J Helminthol

January 2025

Department of Parasitology, Faculty of Veterinary Medicine, University of Firat, 23119, Elazig, Türkiye.

The primary definitive host of the giant acanthocephalan, also known as the giant thorny-headed worm (Pallas, 1781), is . The definitive host ingests the parasite by consuming infected scarabaeoid or hydrophilid beetles. This study aimed to ascertain the presence of in the intermediate hosts through molecular analysis.

View Article and Find Full Text PDF

Inappropriate prescribing of drugs for peptic ulcer and gastro-esophageal reflux disease remains a matter of concern: Results from the LAPTOP-PPI cluster randomized trial.

Front Pharmacol

January 2025

Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

Background: Proton pump inhibitors (PPIs) are among the most commonly and inappropriately prescribed drugs by general practitioners (GPs), resulting in increased risk of adverse outcomes for patients and in avoidable costs for Italy's National Health Service (NHS). This study aims to assess the effectiveness of a low-cost and easily implementable informative intervention directed at GPs to enhance the appropriate prescription of PPIs.

Methods: The LAPTOP-PPI study is a pragmatic, cluster-randomized controlled trial designed to improve the appropriateness of PPI prescriptions among community-dwelling individuals aged ≥65 years.

View Article and Find Full Text PDF

The vacuolar ATPase (V-ATPase; V V ) is a multi-subunit rotary nanomotor proton pump that acidifies organelles in virtually all eukaryotic cells, and extracellular spaces in some specialized tissues of higher organisms. Evidence suggests that metastatic breast cancers mislocalize V-ATPase to the plasma membrane to promote cell survival and facilitate metastasis, making the V-ATPase a potential drug target. We have generated a library of camelid single-domain antibodies (Nanobodies; Nbs) against lipid-nanodisc reconstituted yeast V-ATPase V proton channel subcomplex.

View Article and Find Full Text PDF

Background: Laparoscopic sleeve gastrectomy (LSG) is a potentially refluxogenic operation while Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) is regarded as an anti-reflux procedure. The aim of this study is to compare long-term incidence of Barrett's Oesophagus (BO) and gastroesophageal reflux disease (GORD) following LSG and LRYGB.

Methods: Participants of a double-blinded randomized controlled trial comparing banded LRYGB and LSG for remission of type 2 diabetes were contacted to take part.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!