AI Article Synopsis
- Platelets help stop bleeding and form blood clots when you get hurt, but they also play a big role in the immune system by defending against germs.
- They help control inflammation and support other immune cells to keep our body healthy and fight off infections.
- If platelets get too active, they can cause problems like excessive inflammation and blood clots, which can lead to serious health issues.
Article Abstract
Platelets prevent blood loss during vascular injury and contribute to thrombus formation in cardiovascular disease. Beyond these classical roles, platelets are critical for the host immune response. They guard the vasculature against pathogens via specialized receptors, intracellular signaling cascades, and effector functions. Platelets also skew inflammatory responses by instructing innate immune cells, support adaptive immunosurveillance, and influence antibody production and T cell polarization. Concomitantly, platelets contribute to tissue reconstitution and maintain vascular function after inflammatory challenges. However, dysregulated activation of these multitalented cells exacerbates immunopathology with ensuing microvascular clotting, excessive inflammation, and elevated risk of macrovascular thrombosis. This dichotomy underscores the critical importance of precisely defining and potentially modulating platelet function in immunity.
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| http://dx.doi.org/10.1016/j.immuni.2024.04.008 | DOI Listing |
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