Recent advance in preparation of lignin nanoparticles and their medical applications: A review.

Phytomedicine

Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642 China. Electronic address:

Published: July 2024

Background: Lignin has attracted a lot of attention because it is non-toxic, renewable and biodegradable. Lignin nanoparticles (LNPs) have high specific surface area and specific surface charges. It provides LNPs with good antibacterial and antioxidant properties. LNPs preparation has become clear, however, the application remains in the early stages.

Purpose: A review centric research has been conducted, reviewing existing literature to accomplish a basic understanding of the medical applications of LNPs.

Methods: Initially, we extensively counseled the heterogeneity of lignin from various sources. The size and morphology of LNPs from different preparation process were then discussed. Subsequently, we focused on the potential medical applications of LNPs, including drug delivery, wound healing, tissue engineering, and antibacterial agents. Lastly, we explained the significance of LNPs in terms of antibacterial, antioxidant and biocompatibility, especially highlighting the need for an integrated framework to understand a diverse range of medical applications of LNPs.

Results: We outlined the chemical structure of different type of lignin, and highlighted the advanced methods for lignin nanoparticles preparation. Moreover, we provided an in-depth review of the potential applications of lignin nanoparticles in various medical fields, especially in drug carriers, wound dressings, tissue engineering components, and antimicrobial agents.

Conclusion: This review provides a detailed overview on the current state and progression of lignin nanoparticles for medical applications.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.phymed.2024.155711DOI Listing

Publication Analysis

Top Keywords

lignin nanoparticles
20
medical applications
20
nanoparticles medical
12
lignin
8
specific surface
8
antibacterial antioxidant
8
lnps preparation
8
tissue engineering
8
medical
6
applications
6

Similar Publications

Lignin has emerged as a sustainable alternative to fossil-based polymers in advanced materials such as photonics. However, current methods for preparing photonic lignin materials are limited by non-benign organic solvents and low production yields. In this work, we present a highly efficient process that enables the production of photonic glasses with yields ranging from 48% to 72%, depending on the size of the lignin nanoparticles obtained from herbaceous soda lignin, softwood kraft lignin, and hardwood organosolv lignin.

View Article and Find Full Text PDF

This study explored a facile method for converting macadamia nutshells into bio-based nanomaterials, including cellulose nanofibers (CNFs) and lignin nanoparticles (LNPs), through deep eutectic solvent (DES) pretreatment coupled with a nanofabrication strategy. Comparisons of the physicochemical, morphological, and structural properties of the CNF and LNPs produced through acidic choline chloride/oxalic acid dihydrate (ACDES) and alkaline KCO/glycerol DES (ALDES) pretreatments were conducted using SEM, TEM, FTIR, XRD, TGA, GPC and 2D NMR. The CNFs obtained from ACDES pretreatment (ACCNFs) exhibited uniform and long filament-like structures with shorter whisker-like nanocrystals.

View Article and Find Full Text PDF

The Role of Polyphenols in Abiotic Stress Tolerance and Their Antioxidant Properties to Scavenge Reactive Oxygen Species and Free Radicals.

Antioxidants (Basel)

January 2025

State Key Laboratory of Subtropical Silviculture, College of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.

Plants have evolved complex mechanisms to cope with diverse abiotic stresses, with the phenylpropanoid pathway playing a central role in stress adaptation. This pathway produces an array of secondary metabolites, particularly polyphenols, which serve multiple functions in plant growth, development, regulating cellular processes, and stress responses. Recent advances in understanding the molecular mechanisms underlying phenylpropanoid metabolism have revealed complex regulatory networks involving MYB transcription factors as master regulators and their interactions with stress signaling pathways.

View Article and Find Full Text PDF

Lignin Molar Mass Estimation by Dispersion Analysis.

Macromol Rapid Commun

January 2025

Department of Geosciences and Natural Resource Management, University of Copenhagen, Frederiksberg C, Copenhagen, 1958, Denmark.

Lignin's complex and heterogeneous molecular structure poses significant challenges for accurate molar mass determination, which is important for its utilization in industrial applications, such as biochemicals, nanoparticles, biobased binders, and biofuels. This study evaluates the potential of Taylor Dispersion Analysis (TDA) for measuring lignin size and compares it with size-exclusion chromatography (SEC) and diffusion-ordered spectroscopy (DOSY) NMR. Using dual Gaussian fitting, flow-induced dispersion analysis (FIDA), a TDA-based method, successfully determined the average hydrodynamic radii of multiple species in solvent-fractionated soda grass lignin samples, producing results consistent with DOSY.

View Article and Find Full Text PDF

Construction of curcumin-conjugated pH-responsive lignin-based nanoparticles for alleviating oxidative stress: Stability, antioxidant activity and biocompatibility.

Int J Biol Macromol

January 2025

Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Curcumin has a great effect on alleviating oxidative stress, but its poor stability and low biocompatibility limit its application in therapeutic field. In order to overcome these limitations of curcumin, in this study, curcumin was grafted to lignin by esterification, and then prepared into nanoparticles. The results showed that the photothermal stability of curcumin was effectively improved.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!