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| http://dx.doi.org/10.1177/01410768241255015 | DOI Listing |
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Adherence to antihypertensive medications and associated factors in patients with hypertension, Oromia, Ethiopia: a multicenter study.
Sci Rep
December 2024
School of Public Health, Adama Hospital and Medical College, Adama, Ethiopia.
Interventions designed to improve medication adherence, and blood pressure control have not been effective globally. There is limited comprehensive understanding regarding the level of drug adherence to antihypertensive medications in Ethiopia, particularly in the study area. This study aimed to assess adherence to antihypertensive medication and associated factors among patients with hypertension on follow-up at public health facilities of Adama town, Oromia, Ethiopia.
View Article and Find Full Text PDFHelp-seeking intention for mental illness and associated factors among Dessie town residents in Northeast Ethiopia.
Sci Rep
December 2024
Department of Emergency and Critical Care Nursing, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Despite the increasing global burden of mental illness and the availability of effective evidence-based treatments, many individuals with mental illness do not seek professional help. Therefore, this study aimed to assess help-seeking intention for mental illness and associated factors among Dessie town residents, Northeast Ethiopia, 2021. A community-based cross-sectional study was conducted among 501 Dessie town residents.
View Article and Find Full Text PDFStructure-Activity Relationship Study of Majusculamide D: Overcoming Metabolic Instability and Severe Toxicity with a Fluoro Analogue.
Mar Drugs
November 2024
College of Chemistry, Nankai University, Tianjin 300071, China.
Majusculamide D, isolated from the marine cyanobacterium , is an anticancer lipopentapeptide consisting of fatty acid, tripeptide, and pyrrolyl proline moieties. In this work, by utilizing a convergent synthetic approach, late-stage modification, and bioisostere strategy, 26 majusculamide D analogues were synthesized, and two ( and ) demonstrated IC values < 1 nM against PANC-1 cancer cells. The results summarized a preliminary structure-activity relationship mainly at the C23, C4, C34, and C10 sites.
View Article and Find Full Text PDFEvidence-Based Guidance for One Health Preparedness, Prevention, and Response Strategies to Marburg Virus Disease Outbreaks.
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December 2024
Rwanda Biomedical Center (RBC), Kigali 7162, Rwanda.
Objectives: Marburg virus disease (MVD) is on the WHO list for pandemic-prone pathogens. The current outbreak in Rwanda provides an opportunity to map outbreaks and generate information to inform policymaking, resource mobilization, and guide the implementation of cost-effective response strategies.
Methods: We synthesized available information about MVD to build holistic, up-to-date evidence to inform policymakers, public health leaders, and healthcare and public health services providers in their development and implementation of cost-effective preparedness, prevention, and control measures.
Behavioral and social predictors of COVID-19 vaccine uptake among persons with disabilities in Kenya.
Front Public Health
December 2024
Department of Population Health and Environment, Amref Health Africa, Nairobi, Kenya.
Access and uptake of COVID-19 vaccine by persons with disabilities remains largely unknown in low-and middle-income countries, despite the unique barriers they face, their special vulnerabilities and higher risk to severe outcomes. We aimed to identify behavioral and social predictors of COVID-19 uptake among persons with disability in Kenya. A convergent parallel mixed method study design was conducted among 792 persons with disability in four regions (counties) in Kenya.
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