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Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Alzheimer's Disease Research Center, New York University Langone Health, New York, NY, USA.
Background: Behavioral and psychological symptoms of dementia (BPSD) occur frequently in persons with Alzheimer's disease (PAD). They cause suffering, institutionalization, carepartner distress, depression, burden, and decreased PAD-carepartner quality of life. Brexpiprazole approval advanced the AD treatment armamentarium.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
Milano Bicocca University, Milan, Lombardia Region, Italy.
Background: Nonpharmacological approaches have been identified as first line treatments for the behavioral and psychological symptoms (NPS) of persons living with dementia (PLWD).
Methods: This is a single-arm study to evaluate the feasibility of the TAP approach to promote continuity of care between hospital (S. Gerardo hospital - Italy) and community.
Dementia Care Practice.
Alzheimers Dement
December 2024
University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Individuals with Mild Cognitive Impairment (MCI) and dementia are at greater risk for mental health conditions including depression and anxiety than those without cognitive impairments. Non-pharmacological interventions are considered first-line to address these problems, but access to psychotherapy services for these groups remains limited. Adapted evidence-based therapy approaches, including Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT) are effective for treating comorbid mental health conditions in populations with cognitive impairments.
View Article and Find Full Text PDFThe positive feedback loop between SP1 and MAP2K2 significantly drives resistance to VEGFR inhibitors in clear cell renal cell carcinoma.
Int J Biol Sci
January 2025
Department of Urology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Clear cell renal cell carcinoma (ccRCC) is one of the most common and aggressive malignancies of the urinary system. Despite being the first-line treatment for advanced ccRCC, vascular endothelial growth factor receptor inhibitors (VEGFRis) face significant limitations due to both initial and acquired resistance, which impede complete tumor eradication. Using a CRISPR/Cas9 library screening approach, was identified as a resistance-associated gene for three prevalent VEGFRis (Sunitinib, Axitinib, and Sorafenib).
View Article and Find Full Text PDFThird generation vs first generation EGFR-TKIs in the first line treatment for EGFR-mutated locally advanced or metastatic non-small cell lung cancer: a meta-analysis based on randomized controlled trials.
J Cancer
January 2025
Department of Respiratory and Critical Care Medicine, The Second People's Hospital of Jingdezhen, Jingdezhen, China.
The prevailing belief is that third-generation tyrosine kinase inhibitors (TKIs) targeting the epidermal growth factor receptor (EGFR) (TGET) outperform first-generation EGFR-TKIs (FGET) in managing advanced-stage EGFR-mutated non-small cell lung cancer (NSCLC). However, this standpoint lacks substantiation in evidence-based medicine. Therefore, this meta-analysis was conducted to compare the efficacy and adverse effects (AEs) of these two categories.
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