The exclusion of causes of hypertension is not systematically exploited in clinical practice. Therefore, essential hypertension is consistently presented as the most prevalent 'cause'. The paradox of a condition with unknown causes being described as a common cause of hypertension translates into a diagnosis of essential hypertension in most patients, which precludes the detection of a curable cause of hypertension. The aim of this review is to investigate how the notion of essential hypertension has developed and whether scientific evidence still support the notion of its high prevalence by examining the most recent studies. These studies provided solid scientific evidence that, when systematically sought for, secondary hypertension is quite common and that secondary hypertension is highly prevalent. The increased awareness should lead to a systematic search for, with the goal of curing or achieving a better control of high blood pressure, and ultimately improving patients' quality of life.
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http://dx.doi.org/10.1097/HJH.0000000000003767 | DOI Listing |
Trends Immunol
December 2024
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. Electronic address:
Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid plexus, and perivascular spaces. These innate immune phagocytes are essential in brain development and maintaining homeostasis, but they also play diverse roles in neurological diseases. In this review, we highlight the emerging roles of CNS macrophages in regulating vascular function in health and disease.
View Article and Find Full Text PDFInt J Surg Case Rep
December 2024
Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Introduction: The persistent sciatic artery (PSA) is a rare congenital vascular anomaly that arises when the embryonic axial artery fails to regress, potentially leading to serious complications such as limb ischemia.
Case Presentation: We report the case of a 47-year-old woman with a history of essential hypertension and recent hormonal treatment for uterine fibroids. She developed acute limb ischemia due to bilateral PSA thrombosis, which was confirmed through comprehensive imaging.
Lipids Health Dis
December 2024
Department of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
Background: Cardiometabolic index (CMI) is a comprehensive clinical parameter which integrates overweight and abnormal lipid metabolism. However, its relationship with all-cause, cardiovascular disease (CVD), and cancer mortality is still obscure. Thus, a large-scale cohort study was conducted to illustrate the causal relation between CMI and CVD, cancer, and all-cause mortality among the common American population.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Industrial Engineering, University of Houston, Houston, TX, USA.
Health event prediction is empowered by the rapid and wide application of electronic health records (EHR). In the Intensive Care Unit (ICU), precisely predicting the health related events in advance is essential for providing treatment and intervention to improve the patients outcomes. EHR is a kind of multi-modal data containing clinical text, time series, structured data, etc.
View Article and Find Full Text PDFPathol Res Pract
December 2024
Department of General Biology, Center of Biological Sciences, State University of Londrina (UEL), Londrina 86057-970, Brazil. Electronic address:
Biomarkers that identify tumors with better/worse prognosis can help reduce treatment costs and contribute to patient survival. In urothelial bladder cancer (UBC), accurate prediction of recurrence and progression is essential to inform therapeutic management. Herein, we explore the role of genetic variants of xenobiotic metabolic pathways in UBC susceptibility and prognosis.
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