There has long been conflicting evidence as to how bundled actin filaments, found in cellular structures such as filopodia, are disassembled. In this issue, Chikireddy et al. (https://doi.org/10.1083/jcb.202312106) provide a detailed in vitro analysis of the steps involved in fragmentation of fascin-bundled actin filaments and propose a novel mechanism for severing two-filament bundles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096848 | PMC |
| http://dx.doi.org/10.1083/jcb.202403191 | DOI Listing |
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