AI Article Synopsis
- This study investigates personalized medicine through the use of 3D-printed dosage forms, specifically enteric capsules designed for modified release of the drug ketoprofen.
- It compares two methods of drug release modification using capsules made from different polymer compositions, focusing on pH sensitivity and delayed release.
- Additionally, the research developed a self-nanoemulsifying drug delivery system (SNEDDS) with pomegranate seed oil, enhancing ketoprofen's effectiveness against COX-2, highlighting 3D printing's potential in customized drug delivery systems.
Article Abstract
This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.
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| http://dx.doi.org/10.1021/acsbiomaterials.4c00476 | DOI Listing |
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