Hydrogen sulfide (HS) is considered the third member of the gasotransmitter family, along with nitric oxide (NO) and carbon monoxide (CO). Besides its role in physiological and pathophysiological conditions, the promising therapeutic potential of this small-molecule makes it advantageous for various pharmaceutical applications. The endogenous production of HS at a lower concentration is crucial in maintaining redox balance and cellular homeostasis, and the dysregulation leads to various disease states. In the event of HS deficiency, the exogenous donation of HS could help maintain the optimal cellular concentration of HS and cellular homeostasis. Over the last several years, researchers have developed numerous small-molecule non-fluorogenic organosulfur compounds as HS donors and investigated their pharmacological potentials. However, reports on stimuli-responsive turn-on fluorogenic donors of HS have appeared recently. Interestingly, the fluorogenic HS donors offer additional advantages with the non-invasive real-time monitoring of the HS release utilizing the simultaneous turn-on fluorogenic processes. The review summarizes the recent developments in turn-on fluorogenic donors of HS and the potential biological applications that have developed over the years.
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