AI Article Synopsis
- Rice bran arabinoxylan compound (RBAC) is a natural substance that can help fight cancer and boost the immune system.
- The study looked at many research articles to see how RBAC helps kill cancer cells and improve the effectiveness of cancer treatments like chemotherapy.
- Results showed that RBAC can help patients live longer and have fewer side effects from treatment, but more research is needed to understand how it works and to confirm its benefits.
Article Abstract
Context: Rice bran arabinoxylan compound (RBAC) is a natural immunomodulator with anticancer properties.
Objective: This study critically evaluates the available evidence on the biological pathways of RBAC and its effects on cancer treatment.
Methods: This secondary analysis of a scoping review includes studies evaluating the mechanisms of RBAC on healthy or malignant cells, animal models, or humans for cancer prevention or treatment. Data from randomized controlled trials on survival and quality of life outcomes were subjectd to meta analysis.
Results: The evidence synthesis was based on 38 articles. RBAC exhibited antitumor properties by promoting apoptosis and restoring immune function in cancer patients to enhance inflammatory and cytotoxic responses to block tumorigenesis. RBAC works synergistically with chemotherapeutic agents by upregulating drug transport. In a clinical trial, combining RBAC with chemoembolization in treating liver cancer showed improved response, reduced recurrence rates, and prolonged survival. RBAC also augments the endogenous antioxidant system to prevent oxidative stress and protect against radiation side effects. In addition, RBAC has chemoprotective effects. Animals and humans have exhibited reduced toxicity and side effects from chemotherapy. Meta analysis indicates that RBAC treatment increases the survival odds by 4.02-times (95% CI: 1.67, 9.69) in the first year and 2.89-times (95% CI: 1.56, 5.35) in the second year.
Conclusion: RBAC is a natural product with immense potential in cancer treatment. Additional research is needed to characterize, quantify, and standardize the active ingredients in RBAC responsible for the anticancer effects. More well-designed, large-scale clinical trials are required to substantiate the treatment efficacies further.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097709 | PMC |
| http://dx.doi.org/10.1080/13880209.2024.2349042 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Conservation Analysis and Colorimetric Characterization of Betalain Extracts from the Peel of Red Beetroot, Golden Beetroot, and Prickly Pear Applied to Cottage Cheese.
Foods
January 2025
División de Estudios de Posgrado e Investigación, Instituto Tecnológico de Villahermosa, Tecnológico Nacional de México, Km. 3.5 Carretera, Villahermosa-Frontera, Cd Industrial, Villahermosa 86010, Tabasco, Mexico.
The maintenance of betalains and the color of extracts from the peel of red beetroot (RBAC), golden beetroot (YBAC), and purple prickly pear (PBAC) were evaluated, describing the capacity of their use as natural pigments and in the formulation of attractive and functional foods. Betalain extracts were prepared as juices from frozen and dehydrated peel, adding organic acids and concentrating for water reduction. Extracts were evaluated and applied on cottage cheese, measuring the capacity of betalains retention and pigmentation, during 10 days of storage of closed and opened products.
View Article and Find Full Text PDFContinuous Production of Influenza VLPs Using IC-BEVS and Multi-Stage Bioreactors.
Biotechnol Bioeng
January 2025
Instituto de Biologia Experimental e Tecnológica (iBET), Oeiras, Portugal.
The insect cell-baculovirus expression vector system (IC-BEVS) has been an asset to produce biologics for over 30 years. With the current trend in biotechnology shifting toward process intensification and integration, developing intensified processes such as continuous production is crucial to hold this platform as a suitable alternative to others. However, the implementation of continuous production has been hindered by the lytic nature of this expression system and the process-detrimental virus passage effect.
View Article and Find Full Text PDFCircRNA-RBAC induces cardiac repair by promoting ribosome biogenesis and cell cycle progression in cardiomyocytes.
Int J Biol Macromol
January 2025
Department of Cardiology, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, 510515 Guangzhou, China. Electronic address:
Ribosome biogenesis (RiBi) is an essential process that controls the protein synthesis rate, but its function in regulating endogenous cardiac regeneration remains unknown. Herein, we investigated the function and underlying mechanism of RiBi-associated circRNAs in cardiomyocyte (CM) proliferation and cardiac regeneration. We used high-throughput sequencing, quantitative PCR and in situ hybridization techniques to identify an adult downregulated circRNA, RiBi-associated circRNA (RBAC), in CMs.
View Article and Find Full Text PDFSingle dose of recombinant baculovirus vaccine expressing sigma B and sigma C genes provides good protection against novel duck reovirus challenge in ducks.
Poult Sci
January 2025
Key Laboratory of Avian Bioproducts Developmen, Ministry of Agriculture and Rural Affairs, China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, Yangzhou University, Yangzhou, Jiangsu, China.
Article Synopsis
- The novel duck reovirus disease (NDRV) significantly impacts the waterfowl industry, and currently, there are no commercial vaccines available to combat this infection worldwide.
- Researchers developed two subunit vaccine candidates, σB and σC, using an insect cell-baculovirus expression system (IC-BEVS) to create these vaccines from recombinant viruses targeting NDRV.
- The study found that a single dose of either σB or σC protein improved immune response and overall health in ducklings better than a traditional whole virus vaccine, with the combination of both subunits showing especially strong protective effects.
McHDV VP60 Virus-like Particles Elicit Protective Immunity Against Hemorrhagic Disease in Rabbits.
Pathogens
October 2024
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
viral hemorrhagic disease (McVHD), caused by the hemorrhagic disease virus (McHDV), is an acute and highly fatal infectious disease of musk deer. At present, there is no prevention or treatment for this disease. In this study, we constructed a recombinant bacmid containing the gene and obtained the recombinant baculovirus rBac-McHDV VP60 by transfection into Sf9 () insect cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!