AI Article Synopsis
- * The tumor suppressor p53 plays a key role in regulating various biological processes like cell growth and death, which are linked to the development of fibrosis in different organs.
- * Targeting p53 could provide a new and effective way to prevent or treat organ fibrosis, making it a potential focus for future therapies.
Article Abstract
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in chronic diseases. The tumor suppressor p53 (p53), known for its regulatory roles in cell proliferation, apoptosis, aging, and metabolism across diverse tissues, appears to play a pivotal role in aggravating biological processes such as epithelial-mesenchymal transition (EMT), cell apoptosis, and cell senescence. These processes are closely intertwined with the pathogenesis of fibrotic disease. In this review, we briefly introduce the background and specific mechanism of p53, investigate the pathogenesis of fibrosis, and further discuss p53's relationship and role in fibrosis affecting the kidney, liver, lung, and heart. In summary, targeting p53 represents a promising and innovative therapeutic approach for the prevention and treatment of organ fibrosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094089 | PMC |
| http://dx.doi.org/10.1038/s41419-024-06702-w | DOI Listing |
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