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The pursuit of linear dosage in pharmacy: reservoir-based drug delivery systems from macro to micro scale.
Expert Opin Drug Deliv
January 2025
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Moscow, Russia.
Introduction: The pursuit of linear dosage in pharmacy is essential for achieving consistent therapeutic release and enhancing patient compliance. This review provides a comprehensive summary of zero-order drug delivery systems, with a particular focus on reservoir-based systems emanated from different microfabrication technologies.
Areas Covered: The consideration of recent advances in drug delivery systems is given to encompass the key areas including the importance of achieving a constant drug release rate for therapeutic applications.
Genomic Prediction of Individual Inbreeding Levels for the Management of Genetic Diversity in Populations With Small Effective Size.
Mol Ecol Resour
January 2025
Unit of Animal Genomics, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
In populations of small effective size (N), such as those in conservation programmes, companion animals or livestock species, inbreeding control is essential. Homozygosity-by-descent (HBD) segments provide relevant information in that context, as they allow accurate estimation of the inbreeding coefficient, provide locus-specific information and their length is informative about the "age" of inbreeding. Our objective was to evaluate tools for predicting HBD in future offspring based on parental genotypes, a problem equivalent to identifying segments identical-by-descent (IBD) among the four parental chromosomes.
View Article and Find Full Text PDFAnchorage Accurately Assembles Anchor-Flanked Synthetic Long Reads.
Lebniz Int Proc Inform
August 2024
Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA Department of Computer Science and Engineering, The Pennsylvania State University, University Park, PA, USA.
Modern sequencing technologies allow for the addition of short-sequence tags, known as anchors, to both ends of a captured molecule. Anchors are useful in assembling the full-length sequence of a captured molecule as they can be used to accurately determine the endpoints. One representative of such anchor-enabled technology is LoopSeq Solo, a synthetic long read (SLR) sequencing protocol.
View Article and Find Full Text PDFEffect of SNS addiction on prosocial behavior: mediation effect of fear of missing out.
Front Psychol
December 2024
College of Business, Gachon University, Seongnam, Republic of Korea.
Purpose: This study examines the relationship between social networking sites addiction and pro-social behavior, considering the increasing importance of social networking sites in daily life. It explores the mediating role of Fear of Missing Out in this relationship and investigates the moderating role of basic psychological need satisfaction.
Research Design Data And Methodology: This study employed a snowball sampling method to conduct an online survey among social network users in China.
Unlabelled: Social cognition spans from perceiving agents and their interactions to making inferences based on theory of mind (ToM). Despite their frequent co-occurrence in real life, the commonality and distinction between social interaction perception and ToM at behavioral and neural levels remain unclear. Here, participants ( = 231) provided moment-by-moment ratings of four text and four audio narratives on social interactions and ToM engagement.
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