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Environment and systemic lupus erythematosus. | LitMetric

Environment and systemic lupus erythematosus.

Clin Exp Rheumatol

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Published: May 2024

AI Article Synopsis

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that presents with various symptoms and follows a pattern of flare-ups and remissions.
  • The development of SLE involves a combination of genetic, hormonal, environmental, and other factors, with the exact mechanisms still not fully understood.
  • The review focuses on how environmental factors influence both the occurrence of SLE and the severity of the disease in diagnosed patients.

Article Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations and a relapsing-remitting course. SLE pathogenesis is the result of complex interactions between ethnic, genetic, epigenetic, immunoregulatory, hormonal and environmental factors, and several aspects of these multifactorial connections are still unclear. Overall, for the disease development, an environmental trigger may induce immunological dysfunction in genetically predisposed individuals. This review aims to summarise the most relevant data on the impact of environmental factors on the incidence of SLE and on disease activity and damage in patients with an established diagnosis of SLE.

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Source
http://dx.doi.org/10.55563/clinexprheumatol/17vmqcDOI Listing

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