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Leveraging G-CSF prescribing in the outpatient setting: considerations beyond clinical factors-a questionnaire study. | LitMetric

AI Article Synopsis

  • The study investigates how G-CSF (Granulocyte-Colony Stimulating Factor) is prescribed in outpatient settings for patients with breast, lung, or gastrointestinal cancers, particularly beyond standard guidelines.
  • Conducted with 102 physicians using a simulated chatbot approach, the results show that a majority (84.5%) of doctors prescribe G-CSF, primarily for adjuvant/neoadjuvant therapies, and consider chemotherapy type along with patient-specific factors like age and comorbidities.
  • The findings indicate that G-CSF is mainly prescribed for primary prophylaxis during treatment, with a preference for long-acting versions in breast and lung cancer cases, while short-acting variants are more common for gastrointestinal cancers.

Article Abstract

Purpose: This study aims to delineate G-CSF treatment practices, assess decision criteria, and measure their implementation in ambulatory settings for patients with breast (BC), lung (LC), or gastrointestinal cancers (GIC), beyond standard recommendations.

Methods: In this non-interventional, cross-sectional, multicenter study, clinical cases were presented using conversational interfaces (chatbots), simulating a conversation with one or more virtual interlocutors through voice or text exchange. The clinical simulations were configured by four parameters: types of cancer, risk of FN related to chemotherapy and comorbidities, access to care, and therapy setting (adjuvant/neoadjuvant/metastatic).

Results: The questionnaire was completed by 102 physicians. Most practitioners (84.5%) reported prescribing G-CSF, regardless of tumor type. G-CSF was prescribed more frequently for adjuvant/neoadjuvant therapy than for metastatic cases. The type of chemotherapy was cited as the first reason for prescribing G-CSF, with access to care being the second. Regarding the type of chemotherapy, physicians do not consider this factor alone, but combined with comorbidities and age (56.7% of cases). Pegfilgrastim long-acting was prescribed in most cases of BC and LC (70.1% and 86%, respectively), while filgrastim short-acting was named in the majority of cases of GIC (61.7%); 76.3% of physicians prescribed G-CSF as primary prophylaxis.

Conclusions: Our findings suggest that recommended practices are broadly followed. In the majority of cases, G-CSF is prescribed as primary prophylaxis. In addition, physicians seem more inclined to prescribe G-CSF to adjuvant/neoadjuvant patients rather than metastatic patients. Finally, the type of chemotherapy tends to be a more significant determining factor than the patient's background.

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Source
http://dx.doi.org/10.1007/s00520-024-08524-0DOI Listing

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