Vaginal intraepithelial neoplasia (VaIN), a precancerous lesion associated with human papillomavirus (HPV), impacts women's health and quality of life. However, the natural progression of VaIN after hysterectomy remains uncertain, due to its low incidence. The existing literature predominantly consists of single-center retrospective studies lacking robust evidence-based medicine. The management of VaIN after hysterectomy is diverse and controversial, lacking a consensus on the optimal approach. Therefore, it is imperative to investigate the development of VaIN after hysterectomy, emphasizing the importance of accurate diagnosis and effective management strategies.
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| http://dx.doi.org/10.1007/s00404-024-07530-1 | DOI Listing |
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Vaginal Intraepithelial Neoplasia (VaIN) after Hysterectomy Is Strongly Associated with Persistent HR-HPV Infection.
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Department of General Surgery and Medical-Surgical Specialty, Gynecology and Obstetrics Unit, Rodolico University Hospital, University of Catania, 95123 Catania, Italy.
Unlabelled: The data from the literature show that women undergoing a LEEP due to CIN3 have a greater risk of having subsequent high-grade anogenital intraepithelial neoplasia or cancer, and the risk is greater for vaginal cancer than for anal and vulvar cancers. It is hypothesized that the laparoscopic hysterectomy procedure may cause a higher incidence of VaIN in hysterectomized women. There are few studies addressing this issue, and they show mixed results.
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Article Synopsis
- - The study focuses on the relationship between cervical treatments for precancerous conditions (CIN) and the occurrence of subsequent vaginal neoplasias (VaIN), emphasizing the role of HPV infections, age, and menopausal status as risk factors.
- - A cohort of 275 women was analyzed over six months post-treatment using various methods like laser therapy and hysterectomy, with statistical analysis revealing that radical hysterectomy increased VaIN recurrence.
- - Findings indicated that older and postmenopausal women were at greater risk for severe VaIN and persistent HPV infections, highlighting the need for tailored treatment approaches to manage these risks effectively.
Background: Vaginal Intraepithelial Neoplasia (VaIN) is a prevalent condition that can progress to invasive carcinoma if left untreated. Despite its significance, effective treatments for VaIN remain limited.
Objective: This study aimed to analyze the efficacy of Paiteling in treating VaIN among patients who have undergone total hysterectomy due to high cervical lesions or invasive cervical cancer.
Comprehensive evaluation of vaginal intraepithelial neoplasia development after hysterectomy: insights into diagnosis and treatment strategies.
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Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China.
Vaginal intraepithelial neoplasia (VaIN), a precancerous lesion associated with human papillomavirus (HPV), impacts women's health and quality of life. However, the natural progression of VaIN after hysterectomy remains uncertain, due to its low incidence. The existing literature predominantly consists of single-center retrospective studies lacking robust evidence-based medicine.
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