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Mechanosensitive Ca channel TRPV1 activated by low-intensity pulsed ultrasound ameliorates acute kidney injury through Notch1-Akt-eNOS signaling.
FASEB J
January 2025
Department of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Acute Kidney Injury (AKI) is a significant medical condition characterized by the abrupt decline in kidney function.Low-intensity pulsed ultrasound (LIPUS), a non-invasive therapeutic technique employing low-intensity acoustic wave pulses, has shown promise in promoting tissue repair and regeneration. A novel LIPUS system was developed and evaluated in rat AKI models, focusing on its effects on glomerular filtration rate (GFR), blood urea nitrogen (BUN), serum creatinine (SCr), and the Notch1-Akt-eNOS signaling pathway.
View Article and Find Full Text PDFInvestigation of a flat-type piezoelectric motor using in-plane vibrations.
Rev Sci Instrum
January 2025
School of Perceptual Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
This paper presents a flat-type piezoelectric motor utilizing in-plane vibration modes. Two piezoelectric ceramic plates in combination with a brass metal sheet were used to construct the stator. The superposition of two second order in-plane vibration modes can generate a traveling-wave inside the stator.
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Alzheimers Dement
December 2024
Washington University School of Medicine, St Louis, MO, USA.
Background: It is thought that sleep plays a role in the development and course of Alzheimer's disease (AD). There are numerous metrics and methods to gather sleep data including measures from self-reports, actigraphy, or EEG. There has been limited research examining the reliability of these variables over time in healthy individuals as well as the optimal method to gathering such data.
View Article and Find Full Text PDFCluster perturbation theory. XI. Excitation-energy series using a variational excitation-energy function.
J Chem Phys
January 2025
Hylleraas Centre for Quantum Molecular Sciences, Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, N-0315 Oslo, Norway.
Traditionally, excitation energies in coupled-cluster (CC) theory have been calculated by solving the CC Jacobian eigenvalue equation. However, based on our recent work [Jørgensen et al., Sci.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Background: BACE inhibitors, while effective in lowering amyloid-beta production, have been associated with mild cognitive worsening in clinical trials. Additional treatment-related adverse events reported in multiple clinical trials were sleep disturbances and insomnia. The purpose of this study is to determine if sleep disturbances occur in mice receiving BACE inhibitor, if sleep disturbances correlate with cognitive impairment, and the mechanism by which this may occur.
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