AI Article Synopsis
- Advances in neonatal intensive care have improved survival rates for premature infants, but there's a rise in neonatal hyperoxia lung injury and bronchopulmonary dysplasia (BPD).
- The exact causes of BPD are still unclear, with various prenatal and postnatal factors, along with potential sex differences, influencing its development.
- This paper seeks to review the mechanisms behind neonatal hyperoxic lung injury and BPD, and explore treatment options, aiming to inspire future research in both basic science and clinical applications.
Article Abstract
With the progress in neonatal intensive care, there has been an increase in the survival rates of premature infants. However, this has also led to an increased incidence of neonatal hyperoxia lung injury and bronchopulmonary dysplasia (BPD), whose pathogenesis is believed to be influenced by various prenatal and postnatal factors, although the exact mechanisms remain unclear. Recent studies suggest that multiple mechanisms might be involved in neonatal hyperoxic lung injury and BPD, with sex also possibly playing an important role, and numerous drugs have been proposed and shown promise for improving the treatment outcomes of hyperoxic lung injury. Therefore, this paper aims to analyze and summarize sex differences in neonatal hyperoxic lung injury, potential pathogenesis and treatment progress to provide new ideas for basic and clinical research in this field.
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| http://dx.doi.org/10.1002/ppul.27062 | DOI Listing |
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