AI Article Synopsis
- Apolipoproteins and SCARB1 proteins play a role in HIV-associated lipodystrophy (HIVLD), with specific genetic polymorphisms influencing risk factors for cardiovascular diseases.
- The study examined 3238C/G, 12669G/A, and 1050C/T polymorphisms in 187 HIV patients and 139 healthy controls, finding specific genotypes linked to severe HIVLD and altered lipid levels.
- Overall, while the polymorphisms did not directly modify HIVLD risk, they indicated increased susceptibility when combined with unfavorable lipid and glucose levels.
Article Abstract
Apolipoproteins and Scavenger Receptor Class B1 (SCARB1) proteins are involved in the etiology of HIV-associated lipodystrophy (HIVLD). 3238C/G 12669G/A and 1050C/T polymorphisms were linked with increased level of APOB, TG, HDL-C and risk of cardiovascular diseases (CVDs). Hence, we evaluated the genetic variations of 3238C/G, 12669G/A and 1050C/T in 187 patients of HIV (64 with HIVLD, 123 without HIVLD) and 139 healthy controls using PCR-RFLP and expression by . The genotypes of 1050 TT and 12669AA showed a risk to severe HIVLD (P = 0.23, OR = 4.95; P = 0.16, OR = 2.02). The 3238 GG genotype was associated with a lesser risk of severe HIVLD (P = 0.07, OR = 0.22). The 12669 GA genotype was associated with a greater risk of HIVLD severity in patients with impaired LDL, triglyceride (TG), and cholesterol levels (P = 0.34, OR = 4.13; P = 0.25, OR = 3.64; P = 0.26, OR = 5.47). Similarly, 12669AA genotypes in the presence of impaired triglyceride levels displayed the susceptibility to severity of HIVLD (P = 0.77, OR = 2.91). 12669 GA genotype along with impaired HDL and cholesterol levels indicated an increased risk for HIVLD acquisition among patients without HIVLD (P = 0.42, OR = 2.42; P = 0.26, OR = 2.27). In patients with and without HIVLD, 3238CG genotypes having impaired cholesterol and glucose levels had higher risk for severity and development of HIVLD (P = 0.13, OR = 2.84, P = 0.34, OR = 1.58; P = 0.71, OR = 1.86; P = 0.14, OR = 2.30). An increased expression of and genes were observed in patients with HIVLD (+0.51 vs. -0.93; +4.78 vs. +3.29), and decreased expression of gene was observed in patients with HIVLD (-0.35 vs. -1.65). In conclusion, the polymorphisms mentioned above were not associated with the modulation of HIVLD. However, in the presence of impaired triglyceride, HDL, cholesterol and glucose levels, 12669AA and 12669 GA, 3238CG genotypes indicated a risk for the development and severity of HIVLD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11089352 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e30519 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Correlation of APOE polymorphism, expression, and plasma levels with cardiac comorbidities among lipodystrophy in HIV-infected patients.
Clin Chim Acta
January 2025
Department of Molecular Biology, National AIDS Research Institute Pune 411026, India. Electronic address:
Article Synopsis
- - The study examined the impact of ApoE gene polymorphisms on HIV-related lipodystrophy (HIVLD) and metabolic abnormalities in 200 HIV-infected patients, revealing that certain genotypes might influence the risk of developing these conditions.
- - Results indicated that ApoE alleles 2 and specific genotypes, like 4/4, were connected to a decreased risk of HIV-1 infection and a lower likelihood of severe HIVLD, whereas allele 2 was linked to increased risk of both HIV acquisition and HIVLD severity.
- - Additionally, the study found correlations between specific ApoE genotypes and impaired cholesterol and glucose levels in patients without HIVLD, highlighting the intricate relationship between genetics and metabolic health in the context
Prevalence of clinical characteristics of lipodystrophy in the US adult population in a healthcare claims database.
BMC Endocr Disord
July 2024
Regeneron Pharmaceuticals, Inc. Global Patient Safety, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
Article Synopsis
- Lipodystrophy leads to the progressive loss of fat tissue and various metabolic issues, necessitating a better understanding of its associated health risks in the absence of treatment.
- A study examining data from 2018-2019 revealed that individuals with non-HIV-associated lipodystrophy had significantly higher risks for several conditions like hyperlipidemia, hypertension, and diabetes compared to the general population.
- Furthermore, people with HIV-associated lipodystrophy also faced elevated risks for hypertension, hyperlipidemia, and diabetes when compared to non-HIV patients with lipodystrophy.
Role of APOC3 3238C/G, APOB 12669G/A and SCARB1 1050C/T polymorphisms, their expression in patients of HIV-associated lipodystrophy.
Heliyon
May 2024
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia.
Article Synopsis
- Apolipoproteins and SCARB1 proteins play a role in HIV-associated lipodystrophy (HIVLD), with specific genetic polymorphisms influencing risk factors for cardiovascular diseases.
- The study examined 3238C/G, 12669G/A, and 1050C/T polymorphisms in 187 HIV patients and 139 healthy controls, finding specific genotypes linked to severe HIVLD and altered lipid levels.
- Overall, while the polymorphisms did not directly modify HIVLD risk, they indicated increased susceptibility when combined with unfavorable lipid and glucose levels.
Identification of novel genetic variations in ABCB6 and GRN genes associated with HIV-associated lipodystrophy.
Clin Chim Acta
March 2024
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Article Synopsis
- Protease inhibitors (PIs) have been linked to lipodystrophy, a condition marked by loss of body fat in people living with HIV, with variations in this condition influenced by genetic factors and environmental elements.
- A study sequenced lipid metabolism-related genes in 48 patients, revealing novel genetic variants in the ABCB6 and GRN genes that may be associated with the presence or absence of HIV-related lipodystrophy.
- The findings indicate that specific genetic mutations could affect protein production, potentially worsening lipodystrophy symptoms, while other mutations may help understand the absence of this condition in certain individuals.
Comparative analysis of -493G/T and 34G/A polymorphisms and theirs expression in HIV-associated lipodystrophy patients.
Front Cardiovasc Med
May 2023
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Article Synopsis
- HIV-associated lipodystrophy (HIVLD) is a condition related to abnormal lipid metabolism in HIV-infected individuals, influenced by specific gene polymorphisms affecting lipoprotein transport.
- A study of 187 patients identified the 34A allele and -493T allele as having a non-significant association with reduced severity of HIVLD and lower dyslipidemia risk, respectively.
- Findings suggest that individuals without HIVLD carrying the 34GA genotype have impaired triglyceride levels, indicating a potential increased risk for developing dyslipidemia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!